Park Sarah E, Ma Elaine, Dagenet Caitlyn, Aleshin Maria A, Holahan Heather M, Shi Vivian Y, Hsiao Jennifer L
David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Dermatol Ther (Heidelb). 2025 Jan;15(1):31-44. doi: 10.1007/s13555-024-01319-5. Epub 2024 Dec 11.
Chronic urticaria (CU) is frequently a debilitating skin condition characterized by recurrent and spontaneous wheal and flares with significant impact on quality of life. This systematic review examines the impact of CU on sexual health.
A systematic review using PubMed, Embase, Web of Science, and Cochrane library databases was conducted for articles on sexual health in chronic urticaria.
The database search produced 741 articles, of which 14 articles met inclusion criteria. Study design, patient demographics, disease characteristics, measures used to assess sexuality or sexual function, and study results were independently extracted for each article by two researchers. Any discrepancies were resolved to consensus by a third reviewer. Sexual dysfunction was common in patients with CU and its severity is associated with increased disease activity and poor disease control.
Sexual dysfunction is common in patients with CU, and it negatively affects their quality of life (QoL), body image, sleep quality, and mental health. Incorporating sexual health assessments into CU trials will allow for valuable insights into efficacy of study medications on this important QoL domain. Increased awareness of sexual impairment in CU is needed to provide comprehensive care.
慢性荨麻疹（CU）常常是一种使人衰弱的皮肤病，其特征为反复出现自发性风团及红斑，对生活质量有显著影响。本系统评价旨在探讨CU对性健康的影响。
利用PubMed、Embase、科学网和Cochrane图书馆数据库对关于慢性荨麻疹性健康的文章进行系统评价。
数据库检索得到741篇文章，其中14篇符合纳入标准。两名研究人员分别独立提取每篇文章的研究设计；患者人口统计学资料、疾病特征、用于评估性或性功能的方法以及研究结果。如有任何差异，由第三位审阅者达成共识解决。性功能障碍在CU患者中很常见，其严重程度与疾病活动增加和疾病控制不佳有关。
性功能障碍在CU患者中很常见，它对患者的生活质量（QoL）、身体形象、睡眠质量和心理健康产生负面影响。将性健康评估纳入CU试验将有助于深入了解研究药物在这一重要QoL领域的疗效。需要提高对CU中性功能损害的认识，以便提供全面的护理。
