Morrow A, Quinn P J, Baker K P
J Vet Pharmacol Ther. 1986 Mar;9(1):40-8. doi: 10.1111/j.1365-2885.1986.tb00010.x.
The reactivity of horse skin to intradermal inoculation of histamine, serotonin and bradykinin was investigated, and the resulting reactions compared with those produced in the same horses by a 1% whole-body extract of Culicoides. Both histamine and bradykinin produced large reactions, but there was no significant correlation between the dermal responsiveness to insect allergen and either histamine or bradykinin. Two anti-histamine drugs (promethazine hydrochloride and tripelennamine hydrochloride) were effective in reducing the reaction produced by the insect extract.
研究了马皮对组胺、5-羟色胺和缓激肽皮内接种的反应性，并将由此产生的反应与库蠓1%全身提取物在同一匹马中产生的反应进行比较。组胺和缓激肽均引起强烈反应，但对昆虫变应原的皮肤反应性与组胺或缓激肽之间无显著相关性。两种抗组胺药物（盐酸异丙嗪和盐酸曲吡那敏）可有效减轻昆虫提取物产生的反应。
