Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Drug Discov Ther. 2023 May 15;17(2):87-94. doi: 10.5582/ddt.2022.01109. Epub 2023 Apr 5.
Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted. Therefore, we summarize the mechanisms and indications of DHEA for DOR.
卵巢储备功能减退（DOR）是指正常卵巢功能丧失导致生育能力下降。DOR 与体外受精和胚胎移植（IVF-ET）过程中卵巢刺激的不良反应有关，增加了周期取消率并降低了妊娠率。尽管众所周知脱氢表雄酮（DHEA）可用作与年龄相关疾病的膳食补充剂，但它在许多疾病中的潜力逐渐显现。在这篇综述中，我们重点关注 DHEA 对 DOR 的影响，简要分析其临床益处和局限性，并描述其功能机制和已进行的临床试验。因此，我们总结了 DHEA 治疗 DOR 的机制和适应证。
