McCabe Shannon, Limesand Kirsten, Zhao Ningning
School of Nutritional Sciences and Wellness, The University of Arizona, Tucson, AZ 85721, USA.
Comput Struct Biotechnol J. 2023 Mar 23;21:2332-2338. doi: 10.1016/j.csbj.2023.03.039. eCollection 2023.
ZIP14 is a metal transporter essential for the regulation of body manganese homeostasis. The physiological functions of ZIP14 have been uncovered mainly through two lines of in vivo studies that examined the phenotypes of ZIP14 loss, including studies of humans with mutations and animals with ZIP14 deficiency. This mini review aims at presenting an updated view of the important advances made towards understanding the genetic and pathological mechanisms of brain manganese overload caused by ZIP14 deficiency.
ZIP14是一种对调节机体锰稳态至关重要的金属转运蛋白。ZIP14的生理功能主要通过两类体内研究得以揭示,这些研究考察了ZIP14缺失的表型,包括对携带突变的人类和ZIP14缺陷动物的研究。这篇小型综述旨在呈现一个最新观点,即关于在理解由ZIP14缺陷导致的脑锰过载的遗传和病理机制方面所取得的重要进展。