Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, U.S.A.
Biochem Soc Trans. 2023 Apr 26;51(2):759-769. doi: 10.1042/BST20220925.
In our human society, would you not want to know if your neighbor suddenly passed away? Tissues and cells are not that different. Cell death is an inevitable part of tissue homeostasis and comes in different flavors that can either be a consequence of an injury or a regulated phenomenon (such as programed cell death). Historically, cell death was viewed as a way to discard cells, without functional consequences. Today, this view has evolved and recognizes an extra layer of complexity: dying cells can provide physical or chemical signals to notify their neighbors. Like any type of communication, signals can only be read if surrounding tissues have evolved to recognize them and functionally adapt. This short review aims to provide a summary of recent work interrogating the messenger functions and consequences of cell death in various model organisms.
在人类社会中，你难道不想知道你的邻居是否突然去世了吗？组织和细胞并没有那么不同。细胞死亡是组织稳态的必然组成部分，具有不同的形式，既可以是损伤的结果，也可以是受调控的现象（如程序性细胞死亡）。从历史上看，细胞死亡被视为一种丢弃细胞的方式，而不会产生功能后果。如今，这种观点已经发展，并认识到了额外的复杂性：垂死的细胞可以提供物理或化学信号，以通知它们的邻居。与任何类型的通信一样，只有当周围组织进化到能够识别信号并进行功能适应时，才能读取信号。这篇简短的综述旨在总结最近的工作，探讨各种模式生物中细胞死亡的信使功能和后果。
