Cabon Lauriane, Martinez-Torres Ana-Carolina, Susin Santos A
Inserm U872, équipe 19 « mort cellulaire programmée et physiopathologie des cellules tumorales », Centre de recherche des Cordeliers, Université Pierre et Marie Curie, Université Paris-Descartes, Sorbonne-Universités, UMRS 872, 15, rue de l'École de Médecine, 75006 Paris, France.
Med Sci (Paris). 2013 Dec;29(12):1117-24. doi: 10.1051/medsci/20132912015. Epub 2013 Dec 20.
Apoptosis is nowadays what comes first to your scientist mind when someone mentions cellular suicide. However this is not the sole form of programmed cell death and many other alternative or atypical pathways have now been described. These pathways are indeed rather preferred to apoptosis in some instances based on tissue origin, cell type or development stage of the target cell. In this review, we describe many different programmed cell death subtypes according to their characteristics. Discrete, brutal, final or singular cell death pathways all participate in the elimination of unwanted, damaged or dangerous cells in organisms hence contributing to our knowledge of this particular feature of living beings: dying! Through description of anoikis, necroptosis, entosis, netosis, pyroptosis or ferroptosis, we have no choice but to realize that programmed cell death comes in many flavors.
如今，当有人提及细胞自杀时，凋亡是科学家脑海中首先浮现的概念。然而，这并非程序性细胞死亡的唯一形式，现在已经描述了许多其他替代或非典型途径。基于靶细胞的组织来源、细胞类型或发育阶段，在某些情况下，这些途径确实比凋亡更受青睐。在这篇综述中，我们根据其特征描述了许多不同的程序性细胞死亡亚型。离散的、剧烈的、最终的或独特的细胞死亡途径都参与了生物体中不需要的、受损的或危险细胞的清除，从而有助于我们了解生物的这一特殊特征：死亡！通过对失巢凋亡、坏死性凋亡、内吞凋亡、NETosis、焦亡或铁死亡的描述，我们不得不认识到程序性细胞死亡有多种形式。
