Department of Rehabilitation Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, P. R. China.
MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Small. 2023 Jul;19(30):e2300217. doi: 10.1002/smll.202300217. Epub 2023 Apr 6.
Hepatic ischemia-reperfusion injury (HIRI) is a critical complication after liver surgery that negatively affects surgical outcomes of patients with the end-stage liver-related disease. Reactive oxygen species (ROS) are responsible for the development of ischemia-reperfusion injury and eventually lead to hepatic dysfunction. Selenium-doped carbon quantum dots (Se-CQDs) with an excellent redox-responsive property can effectively scavenge ROS and protect cells from oxidation. However, the accumulation of Se-CQDs in the liver is extremely low. To address this concern, the fabrication of Se-CQDs-lecithin nanoparticles (Se-LEC NPs) is developed through self-assembly mainly driven by the noncovalent interactions. Lecithin acting as the self-assembly building block also makes a pivotal contribution to the therapeutic performance of Se-LEC NPs due to its capability to react with ROS. The fabricated Se-LEC NPs largely accumulate in the liver, effectively scavenge ROS and inhibit the release of inflammatory cytokines, thus exerting beneficial therapeutic efficacy on HIRI. This work may open a new avenue for the design of self-assembled Se-CQDs NPs for the treatment of HIRI and other ROS-related diseases.
肝缺血再灌注损伤（HIRI）是肝手术后的一种严重并发症，对终末期肝病患者的手术结果产生负面影响。活性氧（ROS）是导致缺血再灌注损伤的原因，并最终导致肝功能障碍。具有优异氧化还原响应特性的硒掺杂碳量子点（Se-CQDs）可以有效清除 ROS，保护细胞免受氧化损伤。然而，Se-CQDs 在肝脏中的积累量极低。为了解决这个问题，通过自组装制备了硒掺杂碳量子点-卵磷脂纳米粒子（Se-LEC NPs），主要由非共价相互作用驱动。由于其与 ROS 反应的能力，卵磷脂作为自组装构建块对 Se-LEC NPs 的治疗性能也做出了至关重要的贡献。制备的 Se-LEC NPs 大量积聚在肝脏中，有效清除 ROS 并抑制炎症细胞因子的释放，从而对 HIRI 发挥有益的治疗效果。这项工作可能为设计用于治疗 HIRI 和其他与 ROS 相关疾病的自组装 Se-CQDs NPs 开辟了新途径。
