过氧化物酶催化的硅烷选择性氧化为硅醇。
Peroxygenase-Catalysed Selective Oxidation of Silanes to Silanols.
机构信息
Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629HZ, Delft (The, Netherlands.
Department of Life Sciences, Barcelona Supercomputing Center, Plaza Eusebi Güell 1-3, 08034, Barcelona, Spain.
出版信息
Angew Chem Int Ed Engl. 2023 Jun 12;62(24):e202302844. doi: 10.1002/anie.202302844. Epub 2023 May 4.
A peroxygenase-catalysed hydroxylation of organosilanes is reported. The recombinant peroxygenase from Agrocybe aegerita (AaeUPO) enabled efficient conversion of a broad range of silane starting materials in attractive productivities (up to 300 mM h ), catalyst performance (up to 84 s and more than 120 000 catalytic turnovers). Molecular modelling of the enzyme-substrate interaction puts a basis for the mechanistic understanding of AaeUPO selectivity.
据报道，过氧化物酶催化了有机硅烷的羟化反应。来自田头菇（Agrocybe aegerita）的过氧化物酶（AaeUPO）能够有效地将广泛的硅烷起始原料转化为具有吸引力的产率（高达 300mM·h）和催化剂性能（高达 84s 和超过 120000 个催化循环）。对酶-底物相互作用的分子建模为理解 AaeUPO 选择性提供了基础。
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