Minar E, Ehringer H, Kovacs H, Ahmadi R A, Konecny U, Koppensteiner R, Marosi L, Sommer G
Klin Wochenschr. 1986 Mar 3;64(5):227-30. doi: 10.1007/BF01711653.
The sensitivity of the radiofibrinogen test was investigated to determine the accuracy of the test in diagnosis of venographically proven venous thrombosis in 70 heparinized patients. 125J-fibrinogen was administered between 2 h and 4 days (mean: 1.5 days) after initiating heparin therapy. There were two criteria for a positive test: if the difference between the counts for adjacent points on the same leg or equivalent sites on opposite legs was at least 15%; and/or if there were three adjacent points each with counts greater than 5% that of the same three points on the other leg. The fibrinogen uptake test was positive at the first examination in 67 of 70 patients, giving a sensitivity of 96%. The respective frequencies of truly abnormal results for the 3 X 5% and the 1 X 15% criteria were 94% and 71%. As far as localization and extension of thrombosis were concerned, the fibrinogen uptake test agreed with phlebography in 73% of the cases, when the counts in the groin and the upper third of the thigh were ignored. The 125J-fibrinogen uptake test is an accurate method for detecting established deep leg vein thrombosis even in anticoagulated patients.
对70例接受肝素治疗的患者进行放射性纤维蛋白原试验的敏感性研究，以确定该试验在诊断经静脉造影证实的静脉血栓形成方面的准确性。在开始肝素治疗后2小时至4天（平均1.5天）之间给予125I -纤维蛋白原。阳性试验有两个标准：同一条腿上相邻点或对侧腿上对应部位计数的差异至少为15%；和/或如果有三个相邻点，每个点的计数大于另一条腿上相同三个点计数的5%。在70例患者中，67例在首次检查时纤维蛋白原摄取试验呈阳性，敏感性为96%。对于3×5%和1×15%标准，真正异常结果的相应频率分别为94%和71%。就血栓形成的定位和扩展而言，当忽略腹股沟和大腿上三分之一处的计数时，纤维蛋白原摄取试验在73%的病例中与静脉造影结果一致。125I -纤维蛋白原摄取试验是一种即使在接受抗凝治疗的患者中检测已形成的下肢深静脉血栓的准确方法。
