Vinay V, Jain Sandeep, Abdullah V Yasir, Sharma Amit, Kanna M N Dinesh, Sethi Prabhpreet
Department of TB and Respiratory Diseases, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
J Family Med Prim Care. 2023 Jan;12(1):181-185. doi: 10.4103/jfmpc.jfmpc_1415_22. Epub 2023 Feb 15.
Granulomatosis with polyangiitis (GPA) is an etiologically unknown systemic disease characterized by necrotizing granulomatous inflammation. Additionally, it is accompanied by vasculitis of small and medium-sized blood vessels. It manifests clinically as a triad involving the lungs, upper airways, and kidneys. It is estimated that 90% of patients will exhibit upper or lower airway symptoms and around 80% develops the renal disease. In this article, we describe three case scenarios with varying presentations. GPA should be considered among the possible etiologies of cavitary pulmonary lesions with ear manifestations including hearing loss with poor response to unusual treatment.
肉芽肿性多血管炎（GPA）是一种病因不明的全身性疾病，其特征为坏死性肉芽肿性炎症。此外，它还伴有中小血管的血管炎。临床上表现为肺部、上呼吸道和肾脏受累的三联征。据估计，90%的患者会出现上呼吸道或下呼吸道症状，约80%会发展为肾脏疾病。在本文中，我们描述了三个表现各异的病例。对于伴有耳部表现（包括听力丧失且对非常规治疗反应不佳）的空洞性肺部病变，在可能的病因中应考虑GPA。
