大鼠门体分流后门脑中章鱼胺和酪胺的浓度：通过甲烷化学电离气相色谱-质谱联用同时测定神经胺浓度。

The concentration in brain of octopamine and tyramine after portal-systemic bypass in rats: neuroamine concentrations determined simultaneously by methane chemical ionization gas chromatography mass spectrometry.

作者信息

Meredith C G, Duffield P H, Dougan D F, Duffield A M, Wade D N

出版信息

Life Sci. 1986 May 5;38(18):1701-5. doi: 10.1016/0024-3205(86)90415-7.

Abstract

The concentration in brain of both octopamine (OCT) and tyramine (TYR) was significantly increased in rats 8 weeks after portal-systemic bypass. This suggests that the increase in OCT is secondary to increased decarboxylation of tyrosine to TYR. However, the role these neuroamines, particularly OCT, play in the development of hepatic encephalopathy remains controversial.

摘要

在门体分流术后8周的大鼠中，章鱼胺（OCT）和酪胺（TYR）在脑内的浓度均显著升高。这表明OCT的增加是酪氨酸脱羧生成TYR增加的继发结果。然而，这些神经胺，尤其是OCT，在肝性脑病发展过程中所起的作用仍存在争议。