M J Institute of Ophthalmology, B J Medical College, Ahmedabad, Gujarat, India.
Department of Ophthalmology, Geetanjali Hospital, Udaipur, Rajasthan, India.
Indian J Ophthalmol. 2023 Apr;71(4):1478-1482. doi: 10.4103/IJO.IJO_2838_22.
Dry eye is a prevalent disorder of tear film resulting from either decreased tear production or increased tear evaporation. It is becoming a serious issue due to its disturbing symptoms, which become progressively troublesome affecting the work efficiency of patients and increasing financial burden due to lifelong dependency on eye drops. If not detected early, it can lead to sight-threatening complications. This study aims to explore serum vitamin D3 deficiency as a causative factor of dry eye.
The study was conducted in the outpatient department of a tertiary care hospital in India, for a period of two years from September 2018 to September 2020. About 40 patients who had dry eye and 20 controls were enrolled in this study. They were given an Ocular Surface Disease Index (OSDI) questionnaire, examined for signs of dry eye on slit lamp with Schirmer's test and tear film break-up time. All 60 participants were subjected to serum vitamin D3 level laboratory test and its deficiency prevalence was correlated with dry eye and its severity.
Serum vitamin D3 deficiency was found to be more prevalent in patients with dry eye. There was no gender predilection or change in prevalence with increasing age. Vitamin D3 level was negatively correlated with OSDI and positively with Schirmer's test 1 and 2 and tear film break-up time (TBUT) scores. Conclusion: The prevalence of vitamin D3 deficiency was not consistently found to be associated with the increasing severity of dry eye.
干眼是一种常见的泪膜疾病，由泪液产生减少或泪液蒸发增加引起。由于其症状令人困扰，会逐渐影响患者的工作效率，并因终身依赖眼药水而增加经济负担，因此成为一个严重的问题。如果早期未被发现，它可能会导致威胁视力的并发症。本研究旨在探讨血清维生素 D3 缺乏是否是干眼的一个致病因素。
本研究在印度一家三级护理医院的门诊部进行，时间为 2018 年 9 月至 2020 年 9 月，为期两年。本研究纳入了约 40 名患有干眼的患者和 20 名对照者。他们接受了眼表面疾病指数（OSDI）问卷评估，并在裂隙灯检查下进行了干眼病体征检查，包括 Schirmer 测试和泪膜破裂时间（TBUT）。所有 60 名参与者都进行了血清维生素 D3 水平实验室检测，并将其缺乏的流行率与干眼及其严重程度相关联。
发现患有干眼的患者中血清维生素 D3 缺乏更为普遍。性别无偏好，且缺乏的流行率随年龄增长而变化。维生素 D3 水平与 OSDI 呈负相关，与 Schirmer 测试 1 和 2 以及 TBUT 评分呈正相关。结论：维生素 D3 缺乏的流行率与干眼的严重程度增加不一致相关。
