关于 NCK1 反义 RNA 1（NCK1-AS1）在多种疾病中的作用的综述。
A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders.
机构信息
Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Pathol Res Pract. 2023 May;245:154451. doi: 10.1016/j.prp.2023.154451. Epub 2023 Apr 5.
NCK1 Antisense RNA 1 (NCK1-AS1), alternatively named as NCK1-DT, is a long non-coding RNA (lncRNA) with important roles in the carcinogenesis. Multiple studies verified its oncogenic role in different types of cancer, including gastric cancer, non-small cell lung cancer, glioma, prostate cancer and cervical cancer. NCK1-AS1 functions as a sponge for several microRNAs, including miR-137, miR-22-3p, miR-526b-5p, miR-512-5p, miR-138-2-3p and miR-6857. In this review we present an outline of NCK1-AS1 function in malignant conditions as well as atherosclerosis.
NCK1 反义 RNA1（NCK1-AS1），也称为 NCK1-DT，是一种长链非编码 RNA（lncRNA），在致癌作用中具有重要作用。多项研究证实了其在不同类型癌症中的致癌作用，包括胃癌、非小细胞肺癌、神经胶质瘤、前列腺癌和宫颈癌。NCK1-AS1 作为几种 microRNA 的海绵，包括 miR-137、miR-22-3p、miR-526b-5p、miR-512-5p、miR-138-2-3p 和 miR-6857。在这篇综述中，我们介绍了 NCK1-AS1 在恶性肿瘤和动脉粥样硬化中的作用。
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