Medical College, Yangzhou University, Yangzhou, China; Yangzhou University Medical College, Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Institute of Translational Medicine, Yangzhou University, Jiangsu, Yangzhou, China.
Medical College, Yangzhou University, Yangzhou, China; Yangzhou University Medical College, Jiangsu Key Laboratory of Experimental & Translational Non-coding RNA Research, Institute of Translational Medicine, Yangzhou University, Jiangsu, Yangzhou, China.
Int Immunopharmacol. 2023 May;118:110107. doi: 10.1016/j.intimp.2023.110107. Epub 2023 Apr 6.
In recent years, the study of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome has become a hot topic, especially its role in various tumors. The incidence of hepatocellular carcinoma is ranked in the top five in China. Hepatocellular carcinoma (HCC) is the predominant and typical form of primary liver cancer. Due to the close relationship between NLRP3 inflammasome and cancers, many studies have investigated its role in HCC. The results suggest that NLRP3 inflammasome participates in both tumor growth inhibition and tumor growth promotion in HCC. Therefore, this review elaborates on the relationship between NLRP3 and HCC and explains its role in HCC. In addition, the potential of NLRP3 as a therapeutic target for cancer therapy is explored, summarizing and classifying impacts of and processes underlying different NLRP3 inflammasome-targeting drugs on HCC.
近年来，NOD 样受体热蛋白结构域相关蛋白 3（NLRP3）炎症小体的研究成为热点，特别是其在各种肿瘤中的作用。肝细胞癌在中国的发病率排名前五。肝细胞癌（HCC）是原发性肝癌的主要和典型形式。由于 NLRP3 炎症小体与癌症的密切关系，许多研究已经探讨了其在 HCC 中的作用。结果表明，NLRP3 炎症小体参与 HCC 的肿瘤生长抑制和肿瘤生长促进。因此，本综述详细阐述了 NLRP3 与 HCC 的关系，并解释了其在 HCC 中的作用。此外，还探讨了 NLRP3 作为癌症治疗的治疗靶点的潜力，总结和分类了不同 NLRP3 炎症小体靶向药物对 HCC 的影响和作用机制。
