College of Pharmaceutical Science, Zhejiang University of Technology, Hanzhou 310014, PR China.
College of Pharmaceutical Science, Zhejiang University of Technology, Hanzhou 310014, PR China; Jinhua Polytechnic, Jinhua 321000, PR China.
Fitoterapia. 2023 Jun;167:105501. doi: 10.1016/j.fitote.2023.105501. Epub 2023 Apr 5.
Two new polyketides versicolorones A-B (1-2), one new diketopiperazine derivative aspergiamide B methyl ester (3), along with twenty known compounds 4-23, were obtained from the EtOAc extract of the Cordyceps-colonizing fungus Aspergillus versicolor ZJUTE2. The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the calculated and experimental ECD spectra. In the in-vitro bioassay, compounds 8 and 21 exhibited significant inhibitory activity against the Escherichia coli β-glucuronidase (EcGUS) with IC values of 54.73 ± 2.69 and 56.59 ± 1.77 μM, respectively.
从虫草菌 Colonizing 真菌 Aspergillus versicolor ZJUTE2 的 EtOAc 提取物中获得了两种新的聚酮化合物 versicolorones A-B（1-2），一种新的二酮哌嗪衍生物 aspergiamide B 甲酯（3），以及二十种已知化合物 4-23。通过详细解析光谱数据确定了 1-3 的结构，并通过比较分析计算和实验 ECD 光谱确定了它们的绝对构型。在体外生物测定中，化合物 8 和 21 对大肠杆菌β-葡萄糖醛酸酶（EcGUS）表现出显著的抑制活性，IC 值分别为 54.73±2.69 和 56.59±1.77 μM。
