更新的用于研究多囊卵巢综合征的实验细胞模型。

Updated experimental cellular models to study polycystic ovarian syndrome.

机构信息

Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.

出版信息

Life Sci. 2023 Jun 1;322:121672. doi: 10.1016/j.lfs.2023.121672. Epub 2023 Apr 5.

DOI:10.1016/j.lfs.2023.121672

PMID:37028548

Abstract

Polycystic ovarian syndrome (PCOS) develops due to hormonal imbalance and hyperandrogenism. Animal models are widely used to study PCOS because they mimic essential characteristics of human PCOS; however, the pathogenesis of PCOS remains unclear. Different sources of novel drugs are currently being screened as therapeutic strategies to alleviate PCOS and its symptoms. Simplified cell line in-vitro models could be preliminarily used to screen the bioactivity of various drugs. This review describes different cell line models focusing on the PCOS condition and its complications. Therefore, the bioactivity of the drugs could be preliminarily screened in a cell line model before moving to higher animal models.

摘要

多囊卵巢综合征（PCOS）是由于激素失衡和高雄激素血症引起的。动物模型被广泛用于研究 PCOS，因为它们模拟了人类 PCOS 的基本特征；然而，PCOS 的发病机制仍不清楚。目前正在筛选不同来源的新型药物作为治疗 PCOS 及其症状的策略。简化的细胞系体外模型可以初步用于筛选各种药物的生物活性。本综述描述了不同的细胞系模型，重点介绍了 PCOS 状况及其并发症。因此，在进入更高等动物模型之前，可以在细胞系模型中初步筛选药物的生物活性。