全球骨质疏松症的患病率：一项全面的系统评价和荟萃分析。

The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis.

机构信息

Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

J Orthop Surg Res. 2021 Oct 17;16(1):609. doi: 10.1186/s13018-021-02772-0.

DOI:10.1186/s13018-021-02772-0

PMID:34657598

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8522202/

Abstract

BACKGROUND

Osteoporosis affects all sections of society, including families with people affected by osteoporosis, government agencies and medical institutes in various fields. For example, it involves the patient and his/her family members, and government agencies in terms of the cost of treatment and medical care. Providing a comprehensive picture of the prevalence of osteoporosis globally is important for health policymakers to make appropriate decisions. Therefore, this study was conducted to investigate the prevalence of osteoporosis worldwide.

METHODS

A systematic review and meta-analysis were conducted in accordance with the PRISMA criteria. The PubMed, Science Direct, Web of Science, Scopus, Magiran, and Google Scholar databases were searched with no lower time limit up till 26 August 2020. The heterogeneity of the studies was measured using the I test, and the publication bias was assessed by the Begg and Mazumdar's test at the significance level of 0.1.

RESULTS

After following the systematic review processes, 86 studies were selected for meta-analysis. The sample size of the study was 103,334,579 people in the age range of 15-105 years. Using meta-analysis, the prevalence of osteoporosis in the world was reported to be 18.3 (95% CI 16.2-20.7). Based on 70 studies and sample size of 800,457 women, and heterogenicity I: 99.8, the prevalence of osteoporosis in women of the world was reported to be 23.1 (95% CI 19.8-26.9), while the prevalence of osteoporosis among men of the world was found to be 11.7 (95% CI 9.6-14.1 which was based on 40 studies and sample size of 453,964 men.). The highest prevalence of osteoporosis was reported in Africa with 39.5% (95% CI 22.3-59.7) and a sample size of 2989 people with the age range 18-95 years.

CONCLUSION

According to the medical, economic, and social burden of osteoporosis, providing a robust and comprehensive estimate of the prevalence of osteoporosis in the world can facilitate decisions in health system planning and policymaking, including an overview of the current and outlook for the future; provide the necessary facilities for the treatment of people with osteoporosis; reduce the severe risks that lead to death by preventing fractures; and, finally, monitor the overall state of osteoporosis in the world. This study is the first to report a structured review and meta-analysis of the prevalence of osteoporosis worldwide.

摘要

背景

骨质疏松症影响着社会的各个阶层，包括骨质疏松症患者的家庭、政府机构和各个医学领域的医疗机构。例如，它涉及到患者及其家庭成员，以及政府机构在治疗和医疗保健方面的成本。全面了解全球骨质疏松症的流行情况对于卫生政策制定者做出适当决策非常重要。因此，本研究旨在调查全球骨质疏松症的流行情况。

方法

根据 PRISMA 标准进行系统回顾和荟萃分析。检索了 PubMed、Science Direct、Web of Science、Scopus、Magiran 和 Google Scholar 数据库，没有时间下限，截至 2020 年 8 月 26 日。使用 I 检验测量研究的异质性，并使用 Begg 和 Mazumdar 的检验评估发表偏倚，显著性水平为 0.1。

结果

经过系统审查程序，选择了 86 项研究进行荟萃分析。研究的样本量为 103334579 名 15-105 岁的人群。通过荟萃分析，全球骨质疏松症的患病率为 18.3%（95%置信区间 16.2-20.7）。基于 70 项研究和 800457 名女性的样本量，异质性 I：99.8%，全球女性骨质疏松症的患病率为 23.1%（95%置信区间 19.8-26.9%），而全球男性骨质疏松症的患病率为 11.7%（95%置信区间 9.6-14.1%，基于 40 项研究和 453964 名男性的样本量）。骨质疏松症患病率最高的是非洲，为 39.5%（95%置信区间 22.3-59.7），样本量为 2989 人，年龄在 18-95 岁之间。

结论

根据骨质疏松症的医疗、经济和社会负担，提供全球骨质疏松症患病率的可靠和全面估计，有助于制定卫生系统规划和决策，包括概述当前和未来情况；为骨质疏松症患者的治疗提供必要的设施；通过预防骨折来降低导致死亡的严重风险；最后，监测全球骨质疏松症的整体状况。本研究首次对全球骨质疏松症的患病率进行了结构化综述和荟萃分析。