同源初级 COVID-19 疫苗接种系列后的急性反应：台湾 V-Watch 数据分析。

Acute reactions after a homologous primary COVID-19 vaccination series: Analysis of Taiwan V-Watch data.

机构信息

Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

Health Data Research Center, National Taiwan University, Taipei, Taiwan.

出版信息

Vaccine. 2023 Apr 24;41(17):2853-2859. doi: 10.1016/j.vaccine.2023.03.042. Epub 2023 Mar 28.

DOI:10.1016/j.vaccine.2023.03.042

PMID:37029003

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10043967/

Abstract

INTRODUCTION

The ChAdOx1 nCoV-19 (ChAd), mRNA-1273 (m1273), MVC-COV1901 (MVC), and BNT162b2 (BNT) COVID-19 vaccines received authorization for emergency use in Taiwan beginning in February 2021. We investigated acute reactions to homologous primary COVID-19 vaccination series in adults aged ≥ 18 years.

METHODS

In this prospective observational study based on smartphone data (Taiwan V-Watch), we calculated the frequencies of self-reported local and systemic acute reactions within 7 days of a COVID-19 vaccination, and the health effects up to 3 weeks after each dose. Those who reported adverse reactions after both doses were assessed by the McNemar test.

RESULTS

During 22 March 2021-13 December 2021, 77,468 adults were enrolled; 59.0 % were female and 77.8 % were aged 18-49 years. For both doses of all four vaccines, the local and systemic reactions were minor in severity and highest on days 1 and 2 after vaccination, and declined markedly until day 7. For 65,367 participants who provided data after the first and second doses, systemic reactions were more frequent after dose 2 of the BNT and m1273 vaccines (McNemar tests: both p < 0.001), while local reactions were more frequent after dose 2 of the m1273 and MVC vaccines (both p < 0.001), compared with dose 1 of the homologous vaccine. Among the participants aged 18-49 years, the percentage who missed work on the day after vaccination was slightly higher among women (9.3 %) than among men (7.0 %).

CONCLUSIONS

Acute reactogenicity and impact of work absenteeism for the four COVID vaccines in the V-Watch survey were mild and of short duration.

摘要

简介

腺病毒载体新冠疫苗（ChAd）、mRNA-1273（m1273）、MVC-COV1901（MVC）和 BNT162b2（BNT）于 2021 年 2 月在台湾获得紧急使用授权。我们调查了成年人对同源初级新冠疫苗系列的急性反应。

方法

在这项基于智能手机数据（台湾 V-Watch）的前瞻性观察性研究中，我们计算了 COVID-19 疫苗接种后 7 天内自我报告的局部和全身急性反应的频率，以及每剂后 3 周内的健康影响。那些在两剂后都报告不良反应的人通过 McNemar 检验进行评估。

结果

在 2021 年 3 月 22 日至 2021 年 12 月 13 日期间，共有 77468 名成年人入组；59.0%为女性，77.8%为 18-49 岁。对于所有四种疫苗的两剂，局部和全身反应的严重程度较轻，在接种后第 1 天和第 2 天最高，直到第 7 天明显下降。对于提供第一剂和第二剂后数据的 65367 名参与者，与同源疫苗的第一剂相比，BNT 和 m1273 疫苗的第二剂全身反应更常见（McNemar 检验：均 p<0.001），而 m1273 和 MVC 疫苗的第二剂局部反应更常见（均 p<0.001）。在 18-49 岁的参与者中，接种后第 1 天女性（9.3%）因工作缺勤的百分比略高于男性（7.0%）。