Department of Internal Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Department of Geriatric Medicine, Kocaeli Darica Farabi Training and Research Hospital, Kocaeli, Turkey.
Int Urol Nephrol. 2023 Nov;55(11):2981-2988. doi: 10.1007/s11255-023-03588-z. Epub 2023 Apr 7.
Sarcopenia, associated with morbidity and mortality, is a common geriatric syndrome in older adults. In this study, we investigated the relationship between uric acid, which is a powerful antioxidant and has intracellular proinflammatory activity, and sarcopenia in older adults.
This is a cross-sectional retrospective study involving a total of 936 patients. The diagnosis of sarcopenia was evaluated based on the EGWSOP 2 criteria. The patients were divided into two groups according to hyperuricemia (for females > 6 mg/dl, for males > 7 mg/dl); hyperuricemia and control.
The frequency of hyperuricemia was 65.40%. Patients with hyperuricemia were older than the control group and female gender frequency was higher (p = 0.001, p < 0.001, respectively). Sarcopenia was negatively associated with hyperuricemia as a result of the adjustment analysis made according to demographic characteristics, comorbidities, laboratory results, malnutrition, and malnutrition risk. (p = 0.034). Besides, muscle mass and muscle strength were associated with hyperuricemia (p = 0.026 and p = 0.009, respectively).
Considering the positive effect of hyperuricemia on sarcopenia, avoiding aggressive uric acid-lowering therapy may be a good option in older adults with asymptomatic hyperuricemia.
与发病率和死亡率相关的肌少症是老年人中常见的老年综合征。在这项研究中，我们研究了尿酸与肌少症之间的关系，尿酸是一种强大的抗氧化剂，具有细胞内促炎活性。
这是一项涉及总共 936 名患者的横断面回顾性研究。根据 EGWSOP 2 标准评估肌少症的诊断。根据高尿酸血症（女性> 6mg/dl，男性> 7mg/dl）将患者分为两组；高尿酸血症和对照组。
高尿酸血症的频率为 65.40%。与对照组相比，高尿酸血症患者年龄较大，女性比例较高（p=0.001，p<0.001）。根据人口统计学特征、合并症、实验室结果、营养不良和营养不良风险进行调整分析后，肌少症与高尿酸血症呈负相关（p=0.034）。此外，肌肉质量和肌肉力量与高尿酸血症有关（p=0.026 和 p=0.009）。
鉴于高尿酸血症对肌少症的积极影响，避免积极的降尿酸治疗可能是无症状高尿酸血症老年患者的一个不错选择。
