Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, 510055, P. R. China.
PCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Adv Sci (Weinh). 2023 Jun;10(16):e2206981. doi: 10.1002/advs.202206981. Epub 2023 Apr 8.
In guided bone regeneration surgery, a barrier membrane is usually used to inhibit soft tissue from interfering with osteogenesis. However, current barrier membranes usually fail to resist the impact of external forces on bone-augmented region, thus causing severe displacement of membranes and their underlying bone graft materials, eventually leading to unsatisfied bone augmentation. Herein, a new class of local double-layered adhesive barrier membranes (ABMs) is developed to successfully immobilize bone graft materials. The air-dried adhesive hydrogel layers with suction-adhesion properties enable ABMs to firmly adhere to the wet bone surface through a "stick-and-use" band-aid-like strategy and effectively prevent the displacement of membranes and the leakage of bone grafts in uncontained bone defect treatment. Furthermore, the strategy is versatile for preparing diverse adhesive barrier membranes and immobilizing different bone graft materials for various surgical regions. By establishing such a continuous barrier for the bone graft material, this strategy may open a novel avenue for designing the next-generation barrier membranes.
在引导性骨再生手术中，通常使用屏障膜来抑制软组织干扰成骨。然而，目前的屏障膜通常无法抵抗对骨增强区域的外力影响，从而导致膜及其下的骨移植物材料严重移位，最终导致骨增强效果不理想。在这里，开发了一类新型局部双层粘合屏障膜（ABM），以成功固定骨移植物材料。具有吸气粘附性能的风干粘合水凝胶层使 ABM 能够通过“贴即用”创可贴样策略牢固地粘附在湿骨表面上，并有效地防止膜的位移和无约束骨缺损治疗中骨移植物的泄漏。此外，该策略可用于制备各种粘合屏障膜并固定各种手术区域的不同骨移植物材料，具有多功能性。通过为骨移植物材料建立这种连续屏障，该策略可能为设计下一代屏障膜开辟新途径。
