Department of Colorectal Surgery The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases Guangzhou 510655 P. R. China.
PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat-sen University Guangzhou 510275 P. R. China.
Adv Sci (Weinh). 2021 Mar 5;8(8):2003627. doi: 10.1002/advs.202003627. eCollection 2021 Apr.
Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement of joint movement, lack of antibacterial function, and frequent replacements. Hydrogels have been considered as good candidates for wound dressing because of their good flexibility and biocompatibility. Nevertheless, the adhesive, mechanical, and antibacterial properties of conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted from bacterial cellulose (BC) nanofibers are introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer brushes have rigid BC backbones to enhance mechanical property of hydrogels, realizing high tensile strength (21-51 kPa), large tensile strain (899-1047%), and ideal compressive property. Positively charged quaternary ammonium groups of tethered polymer brushes provide long-lasting antibacterial property to hydrogels and promote crawling and proliferation of negatively charged epidermis cells. Moreover, the hydrogels are rich in catechol groups and capable of adhering to various surfaces, meeting adhesive demand of large movement for special areas. With the above merits, the hydrogels demonstrate less inflammatory response and faster healing speed for in vivo wound healing on rats. Therefore, the multifunctional hydrogels show stable covering, little displacement, long-lasting antibacteria, and fast wound healing, demonstrating promise in wound dressing.
特殊部位伤口的治疗具有挑战性，这是因为这些部位的伤口不可避免地会发生活动，并且固定较为困难。普通的棉纱布存在关节表面覆盖不完全、限制关节运动、缺乏抗菌功能以及需要频繁更换等问题。水凝胶因其良好的柔韧性和生物相容性而被认为是一种很好的伤口敷料候选材料。然而，传统水凝胶的黏附性、机械性能和抗菌性能并不理想。本研究将细菌纤维素（BC）纳米纤维上接枝的阳离子聚电解质刷引入聚多巴胺/聚丙烯酰胺水凝胶中。一维聚合物刷具有刚性的 BC 骨架，可增强水凝胶的机械性能，实现高拉伸强度（21-51 kPa）、大拉伸应变（899-1047%）和理想的压缩性能。固定的聚合物刷上带正电荷的季铵基团为水凝胶提供持久的抗菌性能，促进带负电荷的表皮细胞的爬行和增殖。此外，水凝胶富含儿茶酚基团，能够黏附于各种表面，满足特殊部位大运动的黏附需求。由于具有上述优点，该水凝胶在大鼠体内伤口愈合实验中表现出较低的炎症反应和更快的愈合速度。因此，这种多功能水凝胶具有稳定的覆盖性、较小的位移、持久的抗菌性和快速的伤口愈合能力，有望成为一种理想的伤口敷料。
