Tian Yu-Man, Liu Gao-Bing, Wu Wei-Na, Zhao Xiao-Lei, Han Xue-Feng, Fan Yun-Chang, Wang Yuan, Xu Zhi-Hong
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo 454000, PR China.
Key Laboratory of Chemo/Biosensing and Detection, College of Chemical and Materials Engineering, Xuchang University, Xuchang 461000, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5;296:122669. doi: 10.1016/j.saa.2023.122669. Epub 2023 Mar 27.
Hypochlorite (ClO) is a ROS that plays a crucial role in the immune system in the body. As the largest organelle in the cell, the endoplasmic reticulum (ER) manages various life activities. Thus, a simple hydrazone-based probe was designed, which provided a fast turn-on fluorescent response toward ClO. With a terminal p-toluenesulfonamide group as the endoplasmic reticulum (ER)-specific site, probe 1 was mainly accumulated at ER of living cells, and could be used for imaging endogenous and exogenous HClO in cells and zebrafishes.
次氯酸盐（ClO）是一种活性氧，在人体免疫系统中发挥着关键作用。作为细胞中最大的细胞器，内质网（ER）管理着各种生命活动。因此，设计了一种基于腙的简单探针，它对ClO具有快速开启的荧光响应。探针1以末端对甲苯磺酰胺基团作为内质网（ER）特异性位点，主要积聚在活细胞的内质网中，可用于对细胞和斑马鱼体内的内源性和外源性HClO进行成像。
