Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Diagn Microbiol Infect Dis. 2023 Jun;106(2):115943. doi: 10.1016/j.diagmicrobio.2023.115943. Epub 2023 Mar 18.
The study aimed to investigate the diagnostic efficiency of human neutrophil lipocalin (HNL) in bacterial infections in children.
This study included 49 pediatric patients with bacterial infections, 37 patients with viral infections, 30 patients with autoimmune diseases (AID) and 41 healthy controls (HCs). HNL, procalcitonin (PCT), C-reactive protein (CRP), white blood cell (WBC) and neutrophil counts were detected in the initial diagnosis and the following days.
In the patients with bacterial infections, the levels of HNL, PCT, CRP, WBC and neutrophils were significantly increased than that of disease controls and HCs. The dynamic of these markers was monitored during antibiotic treatment. The level of HNL was decreased rapidly in patients with effective treatment, but maintained at high levels in deteriorated patients according to the clinical progression.
HNL detection is an effective biomarker to identify bacterial infections from viral infections and other AIDs, and has potential value to evaluate the effect of antibiotic treatment in pediatric patients.
本研究旨在探讨人中性粒细胞明胶酶相关脂质运载蛋白（HNL）在儿童细菌感染中的诊断效率。
本研究纳入了 49 例细菌感染患儿、37 例病毒感染患儿、30 例自身免疫性疾病（AID）患儿和 41 例健康对照（HC）。在初始诊断及后续几天检测 HNL、降钙素原（PCT）、C 反应蛋白（CRP）、白细胞（WBC）和中性粒细胞计数。
在细菌感染患儿中，HNL、PCT、CRP、WBC 和中性粒细胞计数均显著高于疾病对照组和 HC。在抗生素治疗期间监测这些标志物的动态变化。根据临床进展，有效治疗的患儿 HNL 水平迅速下降，但病情恶化的患儿仍维持在较高水平。
HNL 检测是一种有效的生物标志物，可用于区分细菌感染与病毒感染和其他 AID，并可能对评估儿科患者的抗生素治疗效果具有潜在价值。
