Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur 768018, Odisha, India.
Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur 768018, Odisha, India.
Int J Biol Macromol. 2023 Jun 15;240:124338. doi: 10.1016/j.ijbiomac.2023.124338. Epub 2023 Apr 7.
Among different forms of cyclodextrin (CD), β-CD has been taken a special attraction in pharmaceutical science due to lowest aqueous solubility and adequate cavity size. β-CD forms inclusion complex with drugs in combination with biopolymers such as polysaccharides which plays a vital role as a vehicle for safe release of drugs. It is noticed that, β-CD assisted polysaccharide-based composite achieves better drug release rate through host-guest mechanism. Present review is a critical analysis of this host-guest mechanism for release of drugs from polysaccharide supported β-CD inclusion complex. Various important polysaccharides such as cellulose, alginate, chitosan, dextran, etc. and their association with β-CD in relevant to drug delivery are logically compared in present review. Efficacy of mechanism of drug delivery by different polysaccharides with β-CD is analytically examined in schematic form. Drug release capacity at different pH conditions, mode of drug release, along with characterization techniques adopted by individual polysaccharide-based CD complexes are comparatively established in tabular form. This review may explore better visibility for researchers those are working in the area of controlled release of drugs by carrier consist of β-CD associated polysaccharide composite through host-guest mechanism.
在不同形式的环糊精（CD）中，β-CD 由于其较低的水溶解度和适当的腔大小，在药物科学中引起了特别的关注。β-CD 与生物聚合物（如多糖）形成药物包合物，在药物的安全释放中起着至关重要的作用。人们注意到，β-CD 辅助的多糖基复合材料通过主客体机制实现了更好的药物释放速率。本综述是对这种通过多糖支持的β-CD 包合物释放药物的主体客体机制的批判性分析。在本综述中，逻辑地比较了各种重要的多糖，如纤维素、藻酸盐、壳聚糖、葡聚糖等，以及它们与药物输送相关的β-CD 之间的联系。以示意图形式分析了不同多糖与β-CD 药物传递机制的功效。以表格形式比较了在不同 pH 值条件下的药物释放能力、药物释放模式以及各个基于多糖的 CD 配合物采用的表征技术。通过主客体机制，通过包含β-CD 的多糖复合载体控制药物释放的研究人员可能会更好地了解这一领域。
