Van Dam Jago M, Graetz Lynton, Pitcher Julia B, Goldsworthy Mitchell R
Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia; Lifespan Human Neurophysiology Group, School of Biomedicine, University of Adelaide, Adelaide, South Australia 5000, Australia; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia.
Lifespan Human Neurophysiology Group, School of Biomedicine, University of Adelaide, Adelaide, South Australia 5000, Australia; Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia.
Brain Res. 2023 Jul 1;1810:148359. doi: 10.1016/j.brainres.2023.148359. Epub 2023 Apr 6.
The neuroplastic response to continuous theta burst stimulation (cTBS) is inherently variable. The measurement of I-wave latencies has been shown to strongly predict the magnitude and direction of the response to cTBS, whereby longer latencies are associated with stronger long-term depression-like responses. However, potential differences in this association relating to age and sex have not been explored. We performed cTBS and measured I-wave recruitment (via MEP latencies) in 66 participants (31 female) ranging in age from 11 to 78 years. The influence of age and sex on the association between I-wave recruitment and the response to cTBS was tested using linear regression models. In contrast to previous studies, there was not a significant association between I-wave latencies and cTBS response at the group level (p = 0.142, R = 0.033). However, there were interactions between I-waves and both age and sex when predicting cTBS response. Subgroup analysis revealed that preferential late I-wave recruitment predicted cTBS response in adolescent females, but not in adolescent or adult males or adult females. These data suggest that the generalisability of I-wave measurement in predicting the response to cTBS may be lower than initially believed. Prediction models should include age and sex, rather than I-wave latencies alone, as our findings suggest that, while each factor alone is not a strong predictor, these factors interact to influence the response to cTBS.
对连续theta爆发刺激（cTBS）的神经可塑性反应本质上是可变的。I波潜伏期的测量已被证明能强烈预测对cTBS的反应幅度和方向，即较长的潜伏期与较强的长期抑郁样反应相关。然而，尚未探讨这种关联在年龄和性别方面的潜在差异。我们对66名年龄在11至78岁之间的参与者（31名女性）进行了cTBS，并测量了I波募集情况（通过运动诱发电位潜伏期）。使用线性回归模型测试了年龄和性别对I波募集与cTBS反应之间关联的影响。与先前的研究不同，在组水平上I波潜伏期与cTBS反应之间没有显著关联（p = 0.142，R = 0.033）。然而，在预测cTBS反应时，I波与年龄和性别之间存在相互作用。亚组分析显示，优先晚期I波募集可预测青春期女性的cTBS反应，但不能预测青春期或成年男性或成年女性的反应。这些数据表明，I波测量在预测cTBS反应方面的普遍性可能低于最初的认识。预测模型应包括年龄和性别，而不是仅包括I波潜伏期，因为我们的研究结果表明，虽然每个因素单独而言都不是强有力的预测指标，但这些因素相互作用会影响对cTBS的反应。
