Maher J F, Hirszel P, Chakrabarti E, Bennett R R
Nephron. 1986;43(1):38-42. doi: 10.1159/000183715.
To distinguish amphotericin B effects on peritoneal transport from those of the solvent, sodium desoxycholate, dialyses in intact rabbits with either substance added intraperitoneally were compared to controls. Powered amphotericin B added to instilled dialysis fluid increased peritoneal ultrafiltration from 0.31 to 0.44 ml/kg/min (p less than 0.02), but did not affect mass transport (e.g. urea clearance changed from 0.86 to 1.04 ml/kg/min). In contrast, 10 mg of desoxycholate induced peritoneal irritation and raised clearances of urea (0.76-1.34 ml/kg/min), potassium, phosphate and dextrose, but did not affect ultrafiltration. Intraperitoneally, 1 mg/kg of desoxycholate changed clearances inconsistently, but lowered the ultrafiltration rate from 0.33 to 0.21 ml/kg/min. The dialysate-plasma dextrose gradient dissipated faster with 10 mg/kg of desoxycholate. Amphotericin B tended to raise ultrafiltration per osmotic gradient and mass transport of sodium. Selective increase in fluid flux results from amphotericin B, not its solvent.
为了区分两性霉素B对腹膜转运的影响与溶剂脱氧胆酸钠的影响，将腹膜内添加这两种物质的完整兔的透析与对照组进行了比较。添加到注入的透析液中的两性霉素B粉末使腹膜超滤从0.31增加到0.44毫升/千克/分钟（p<0.02），但不影响物质转运（例如尿素清除率从0.86变为1.04毫升/千克/分钟）。相比之下，10毫克脱氧胆酸钠引起腹膜刺激并提高了尿素（0.76 - 1.34毫升/千克/分钟）、钾、磷酸盐和葡萄糖的清除率，但不影响超滤。腹膜内注射1毫克/千克脱氧胆酸钠对清除率的影响不一致，但使超滤率从0.33降至0.21毫升/千克/分钟。10毫克/千克脱氧胆酸钠使透析液 - 血浆葡萄糖梯度消散得更快。两性霉素B倾向于提高每渗透梯度的超滤和钠的物质转运。两性霉素B导致的液体通量选择性增加，而非其溶剂。
