Maher J F, Hirszel P, Bennett R R, Chakrabarti E
Am J Kidney Dis. 1984 Nov;4(3):285-8. doi: 10.1016/s0272-6386(84)80106-7.
Because amphotericin B is known to affect transport rates across biologic membranes, the effects of this agent on transport parameters in an animal model of peritoneal dialysis were investigated. When amphotericin B in doses ranging from 0.5 to 25 mg/kg was instilled intraperitoneally with commercial dialysis solution, diffusive clearances of phosphate and urea did not differ from control values measured in the same animals, and only a modest increase in potassium clearance was detected. Ultrafiltration due to the osmotic gradient induced by the dextrose content of the dialysis solution increased significantly to 0.31 mL/kg/min with amphotericin B, compared with control values of 0.18 mL/kg/min. The drug did not affect dextrose transport and the osmotic gradient did not differ in the two groups. Hence, the ultrafiltration coefficient was higher with amphotericin B (14 microL/kg/min/mosm), than during control dialyses (6 microL/kg/min/mosm). Increased water flux was detected at the lowest dose and there was no dose relationship over the range studied. Amphotericin B may be the type of agent that will be clinically useful in patients with reduced peritoneal ultrafiltration capacity, and safer analogues should be explored.
由于已知两性霉素B会影响生物膜的转运速率，因此研究了该药物对腹膜透析动物模型中转运参数的影响。当将剂量范围为0.5至25mg/kg的两性霉素B与市售透析液一起腹腔内注入时，磷酸盐和尿素的扩散清除率与在同一动物中测得的对照值无差异，仅检测到钾清除率有适度增加。与对照值0.18 mL/kg/min相比，两性霉素B使由透析液中葡萄糖含量诱导的渗透梯度引起的超滤显著增加至0.31 mL/kg/min。该药物不影响葡萄糖转运，两组的渗透梯度无差异。因此，两性霉素B组的超滤系数（14 μL/kg/min/ mosm）高于对照透析时（6 μL/kg/min/ mosm）。在最低剂量时检测到水通量增加，并且在所研究的范围内没有剂量关系。两性霉素B可能是对腹膜超滤能力降低的患者临床上有用的药物类型，应探索更安全的类似物。
