Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fertility and Infertility Research Centre, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Curr Med Chem. 2024;31(28):4562-4577. doi: 10.2174/0929867330666230409003744.
The present study evaluated the anti-arthritic impact of combined crocin and curcumin on Adjuvant Induced Arthritis (AIA) in rats.
The arthritis model was induced in rats by injecting Complete Freund's adjuvant (CFA) into the right hind paw and was subsequently treated with crocin and curcumin. Evaluation of anti- arthritic activity was carried out using paw swelling, hematological parameters, biochemical parameters, inflammatory cytokines, and histopathology of rats.
The results showed increased paw swelling, increased serum markers levels, including CRP, RF, ALP, ALT, and AST, and inflammatory cytokines (ILlβ and TNFα) along with histology changes (cartilage and bone degradation) in arthritic rats when compared to the normal group. Crocin, curcumin and crocin + curcumin administration at different doses (especially combination at 40 mg/kg and 30 mg/kg, respectively), as well as MTX, revealed a suitable therapeutic effect on AIA rats. Moreover, both phytochemicals and their combination at different doses showed effective anti- arthritic effects owing to their anti-inflammatory effects.
Crocin and curcumin, either alone or in combination, can be a suitable treatment modality for rheumatoid arthritis.
本研究评估了藏红花酸和姜黄素联合应用对大鼠佐剂性关节炎（AIA）的抗关节炎作用。
通过向大鼠右后爪注射完全弗氏佐剂（CFA）诱导关节炎模型，随后用藏红花酸和姜黄素进行治疗。通过大鼠爪肿胀、血液学参数、生化参数、炎性细胞因子和组织病理学评估抗关节炎活性。
与正常组相比，关节炎大鼠的爪肿胀增加，血清标志物水平（包括 CRP、RF、ALP、ALT 和 AST）和炎性细胞因子（ILlβ 和 TNFα）升高，同时伴有组织学变化（软骨和骨降解）。藏红花酸、姜黄素和藏红花酸+姜黄素以不同剂量（特别是分别以 40mg/kg 和 30mg/kg 联合使用）以及 MTX 给药对 AIA 大鼠具有合适的治疗作用。此外，由于其抗炎作用，两种植物化学物质及其不同剂量的联合使用均显示出有效的抗关节炎作用。
藏红花酸和姜黄素单独或联合使用可能是治疗类风湿关节炎的一种合适的治疗方法。
