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尿毒症合并子痫前期患者剖宫产术后自发性肝出血:病例报告。

Spontaneous hepatic haemorrhage after caesarean section in a patient with uraemia and superimposed preeclampsia: a case report.

机构信息

Department of Critical Care Medicine, Anqing Municipal Hospital, Anqing City, Anhui Province, China.

Cardiovascular Department, Anqing Municipal Hospital, Anqing City, Anhui Province, China.

出版信息

J Int Med Res. 2023 Apr;51(4):3000605231166510. doi: 10.1177/03000605231166510.

Abstract

Perinatal spontaneous hepatic haemorrhage is a very rare disease affecting pregnant women, particularly those on long-term dialysis, that has a high maternal and infant mortality rate. Most patients experience preeclampsia with haemolysis, elevated liver enzymes and low platelets syndrome. Here, the case of a 35-year-old multigravida patient with known chronic kidney disease and chronic hypertension with uraemia, who developed spontaneous hepatic haemorrhage after caesarean section, is described. The patient experienced sudden massive circulatory failure, but hemodynamics were temporarily stabilized after emergency surgery. Following transfer to the intensive care unit for continued treatment, her blood pressure and haemoglobin level continued to drop. Selective hepatic artery embolization was performed on day 2 after delivery, and her vital signs gradually stabilized. On day 30 after delivery, the patient was discharged in a stable condition. The newborn recovered after therapy in neonatal intensive care for 2 months. The present case suggests that, for perinatal spontaneous hepatic haemorrhage, timely and accurate diagnosis, multidisciplinary management and determining the therapeutic approach according to clinical symptoms are essential.

摘要

围生期自发性肝出血是一种罕见疾病,影响孕妇,特别是长期透析的孕妇,具有较高的母婴死亡率。大多数患者表现出先兆子痫伴溶血、肝酶升高和血小板减少综合征。本文描述了一例 35 岁多产妇,患有已知的慢性肾脏病和慢性高血压合并尿毒症,在剖宫产术后发生自发性肝出血。患者出现突然的大量循环衰竭,但在紧急手术后血流动力学暂时稳定。转入重症监护病房继续治疗后,血压和血红蛋白水平持续下降。在分娩后第 2 天行选择性肝动脉栓塞,生命体征逐渐稳定。分娩后第 30 天,患者病情稳定出院。新生儿在新生儿重症监护室治疗 2 个月后康复。本病例提示,对于围生期自发性肝出血,及时准确的诊断、多学科管理以及根据临床症状确定治疗方法至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8566/10107969/9e1e5752bfb1/10.1177_03000605231166510-fig1.jpg

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