The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies.
作者信息
Souroujon M C, Pachner A R, Fuchs S
出版信息
Neurology. 1986 May;36(5):622-5. doi: 10.1212/wnl.36.5.622.
PMID:3703261
Abstract
Experimental autoimmune myasthenia gravis (EAMG) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding site of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.
摘要
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