实验性自身免疫性重症肌无力的一种新模型。
A new model of experimental auto-immune myasthenia gravis.
作者信息
Souan M L, Geffard M
出版信息
J Neuroimmunol. 1985 Oct;9(6):327-38. doi: 10.1016/s0165-5728(85)80033-3.
Experimental auto-immune myasthenia gravis (EAMG) was observed in rabbits during the time course of immunization with an acetylcholine (ACh) conjugate: choline-glutaryl-protein. This synthesized antigenic determinant mimics the molecular structure of ACh. The presence of both anti-ACh and auto-anti-idiotypic antibodies was demonstrated. These latter antibodies recognized the ACh receptor, and could have been the triggering agents in this auto-immune condition. Clinical and electromyographic investigations confirmed the myasthenic symptomatology observed after immunization with the ACh conjugate.
在用乙酰胆碱（ACh）结合物：胆碱 - 戊二酰 - 蛋白免疫家兔的过程中，观察到了实验性自身免疫性重症肌无力（EAMG）。这种合成的抗原决定簇模拟了ACh的分子结构。证实了抗ACh抗体和自身抗独特型抗体的存在。这些抗独特型抗体识别ACh受体，可能是这种自身免疫状态的触发因素。临床和肌电图检查证实了用ACh结合物免疫后观察到的重症肌无力症状。
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