Department of Renal Medicine, Monash University Eastern Health Clinical School, Box Hill, VIC, Australia.
Department of Renal Medicine, Eastern Health, Box Hill, VIC, Australia.
Front Endocrinol (Lausanne). 2023 Mar 23;14:1146868. doi: 10.3389/fendo.2023.1146868. eCollection 2023.
With increasing life expectancy, the related disorders of bone loss, metabolic dysregulation and sarcopenia have become major health threats to the elderly. Each of these conditions is prevalent in patients with chronic kidney disease (CKD), particularly in more advanced stages. Our current understanding of the bone-muscle interaction is beyond mechanical coupling, where bone and muscle have been identified as interrelated secretory organs, and regulation of both bone and muscle metabolism occurs through osteokines and myokines autocrine, paracrine and endocrine systems. This review appraises the current knowledge regarding biochemical crosstalk between bone and muscle, and considers recent progress related to the role of osteokines and myokines in CKD, including modulatory effects of physical exercise and potential therapeutic targets to improve musculoskeletal health in CKD patients.
随着预期寿命的延长，与骨丢失、代谢失调和肌肉减少症相关的疾病已成为老年人的主要健康威胁。这些疾病在慢性肾脏病（CKD）患者中都很普遍，尤其是在更晚期的患者中。我们目前对骨-肌相互作用的理解已经超越了机械耦联，骨和肌肉已被确定为相互关联的分泌器官，骨和肌肉代谢的调节通过骨源因子和肌源因子的自分泌、旁分泌和内分泌系统发生。这篇综述评估了目前关于骨与肌肉之间生化串扰的知识，并考虑了与骨源因子和肌源因子在 CKD 中的作用相关的最新进展，包括身体运动的调节作用和改善 CKD 患者肌肉骨骼健康的潜在治疗靶点。
