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A mechanosensory defect in a amyloid-beta glutamatergic neuron model is reversed following exposure to species extracts.

作者信息

Schlein Melissa L, Arituluk Zekiye Ceren, Stephen Cayman A, Caldwell Guy A, Ciesla Lukasz, Caldwell Kim A

机构信息

Biological Sciences, The University of Alabama, Tuscaloosa Alabama USA.

出版信息

MicroPubl Biol. 2023 Mar 20;2023. doi: 10.17912/micropub.biology.000780. eCollection 2023.

DOI:10.17912/micropub.biology.000780
PMID:37033702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10074171/
Abstract

Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few (sage) species. Here, six new species were isolated during flowering times from plants native to Turkey. Extracts were prepared and then examined for their potential to rescue both anterior and posterior mechanosensory behavioral defects in a transgenic Alzheimer's disease model that expresses human amyloid-beta (Aβ) peptide (1-42) exclusively in the glutamatergic neurons. Extracts from all six species rescued anterior touch response defects while only three rescued posterior touch response defects, compared to the Aβ controls.

摘要

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本文引用的文献

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