Testa Michael D, Remsburg Carolyn M, Song Jia L
University of Delaware, Newark, Delaware, United States.
MicroPubl Biol. 2023 Mar 21;2023. doi: 10.17912/micropub.biology.000717. eCollection 2023.
Fascin is a conserved protein that has been shown to modulate the cytoskeleton. Its role in early development remains unclear. After fertilization, embryos undergo rapid cell divisions, requiring the precise regulation of cytoskeleton to segregate chromosomes. Results indicate that Fascin is in the cell cortex, enriched in the perinuclear region of non-dividing blastomeres and on the mitotic spindle of dividing blastomeres of the early embryo. Loss-of-function of Fascin leads to a significant developmental delay or arrest, indicating that Fascin is important for proper early embryonic development.
Fascin是一种保守蛋白，已被证明可调节细胞骨架。其在早期发育中的作用尚不清楚。受精后，胚胎经历快速细胞分裂，这需要精确调节细胞骨架以分离染色体。结果表明，Fascin存在于细胞皮层中，在未分裂的卵裂球的核周区域以及早期胚胎分裂的卵裂球的有丝分裂纺锤体上富集。Fascin功能丧失会导致显著的发育延迟或停滞，表明Fascin对早期胚胎的正常发育很重要。
