Alsharif Sahar Hasan, Alghamdi Asail Saeed, Alhumaidi Wareef Abdulkarim, AlRobaish Omar Abdulaziz, Al Hamoud Mohammad Hassan, Alruwaili Asma Saleh, AlQefari Ghaida B, Almutairi Rahaf Tayi
Department of Dermatology, Ministry of Health, Makkah, Saudi Arabia.
Department of Medicine, Albaha University, Albaha, Saudi Arabia.
Clin Cosmet Investig Dermatol. 2023 Apr 2;16:837-845. doi: 10.2147/CCID.S405715. eCollection 2023.
Stretch marks, also known as striae cutis distensae (SD), are visible linear scars that occur in regions of dermal damage due to skin stretching. Stretch marks are not serious health issues, but they may have a major psychological effect on patients. Due to poor skin color improvement or prolonged skin atrophy, there is no standard treatment for SD. Fillers have been studied for their effectiveness in the treatment of SD.
This systematic review aims to determine the efficacy of fillers on SD.
This systematic review is reported following PRISMA guidance. We included all relevant articles published up to November 2022 in the following electronic databases: Science Direct, Midline, the Web of Science, CINAHL, and Google Scholar. The initial search yielded 119, of which seven were included after applying inclusion and exclusion criteria.
The systematic review included a total of 184 female participants who were over the age of 18 years old. Three studies used jet volumetric remodeling (JVR) to inject HA pneumatically. One study injected polycaprolactone filler. One study used calcium hydroxylapatite, micro-needling, and ascorbic acid. MFU-V and CaHA were given in one study. One study delivered MFU-V using micro-focused ultrasound. All studies showed that it reduces SD with only mild, temporary side effects. More favor was given to combining CaHA and MFU-V, which had the fewest side effects compared to other dermal fillers.
As monotherapy or combination therapy, injectable dermal fillers may treat SD with minimal adverse effects. We suggest that more RCTs look into injectable dermal filler to find out what is best for patients with SD and compare it to other treatment methods in terms of results, costs, and side effects to provide satisfactory practice and basic guideline interventions for these cases.
膨胀纹，也称为皮肤扩张纹（SD），是由于皮肤拉伸导致真皮损伤区域出现的可见线性瘢痕。膨胀纹并非严重的健康问题，但可能对患者产生重大心理影响。由于皮肤颜色改善不佳或皮肤萎缩持续时间较长，目前尚无治疗SD的标准方法。人们已对填充剂治疗SD的有效性进行了研究。
本系统评价旨在确定填充剂治疗SD的疗效。
本系统评价按照PRISMA指南进行报告。我们纳入了截至2022年11月在以下电子数据库中发表的所有相关文章：Science Direct、Medline、科学网、护理学与健康领域数据库（CINAHL）和谷歌学术。初步检索得到119篇文章，应用纳入和排除标准后纳入7篇。
该系统评价共纳入184名年龄超过18岁的女性参与者。三项研究使用喷射式容积重塑（JVR）气动注射透明质酸（HA）。一项研究注射聚己内酯填充剂。一项研究使用羟基磷灰石钙、微针和抗坏血酸。一项研究同时给予微聚焦超声（MFU-V）和羟基磷灰石钙（CaHA）。一项研究使用微聚焦超声进行MFU-V治疗。所有研究均表明，其可减轻SD，且仅伴有轻微、短暂的副作用。更倾向于联合使用CaHA和MFU-V，与其他真皮填充剂相比，其副作用最少。
作为单一疗法或联合疗法，可注射真皮填充剂治疗SD的不良反应最小。我们建议更多的随机对照试验（RCT）研究可注射真皮填充剂，以确定哪种对SD患者最有效，并在结果、成本和副作用方面与其他治疗方法进行比较，为这些病例提供满意的实践和基本指导干预措施。
