Kessler J P, Jean A
Neurosci Lett. 1986 Mar 28;65(1):41-6. doi: 10.1016/0304-3940(86)90117-5.
Swallowing is a polysynaptic reflex organized by a neuronal network localized mainly within the lateral region of the nucleus tractus solitarius (NTS). Monoamine microinjections (serotonin, noradrenaline; 1 nmol, 50 nl) within the swallowing region of the NTS produced a significant decrease in the number of swallows elicited by repetitive stimulation of the superior laryngeal nerve. Stimulation, with concentric bipolar electrodes, of several brainstem structures overlapping monoaminergic regions such as the nucleus raphe magnus, the nucleus raphe pallidus, the lemniscus medialis, the ventrolateral reticular formation, the locus coeruleus and the nucleus commissuralis, induced an inhibition of the laryngeal-initiated swallowing. These results indicate the existence, within the NTS, of a monoaminergic inhibition of the swallowing reflex which might originate from monoaminergic brainstem regions.
吞咽是一种多突触反射，由主要位于孤束核（NTS）外侧区域的神经网络组织。在NTS吞咽区域内微量注射单胺类物质（5-羟色胺、去甲肾上腺素；1纳摩尔，50纳升），可使重复刺激喉上神经所诱发的吞咽次数显著减少。用同心双极电极刺激几个与单胺能区域重叠的脑干结构，如中缝大核、中缝苍白核、内侧丘系、腹外侧网状结构、蓝斑和连合核，可抑制由喉部引发的吞咽。这些结果表明，在NTS内存在对吞咽反射的单胺能抑制，其可能源自脑干单胺能区域。
