Qasem Khalil M A, Khan Shabnam, Shahid M, Saleh Hatem A M, Ghanem Younes S A, Qashqoosh Mohsen T A, Ahmad Musheer
Functional Inorganic Materials Lab (FIML), Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
Department of Applied Chemistry (ZHCET), Aligarh Muslim University, Aligarh 202002, India.
ACS Omega. 2023 Mar 23;8(13):12232-12245. doi: 10.1021/acsomega.2c08231. eCollection 2023 Apr 4.
Nowadays, the fabrication of 2D metal-organic nanosheets (2D MONs) has entered the research arena fascinating researchers worldwide. However, a lack of efficient and facile methods has remained a bottleneck for the manufacturing of these 2D MONs. Herein, a 2D metal-organic framework (MOF), i.e., 2D Cu-MOF, was synthesized using a facile and convenient stirring method by using 4,4'-trimethylenedipyridine (TMDP) as an organic linker. The as-prepared MOF was characterized in detail and based on single crystal X-ray diffraction analysis, it was established that tangled layers in the 2D Cu-MOF are interconnected to produce thick strands. These tangled layers could be easily separated via ultrasonication-induced liquid phase exfoliation (UILPE) to give the 2D Cu-MON as illustrated through Tyndall light scattering and exhaustive microscopic exploration such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The application of this 2D Cu-MON was assessed in the field of drug delivery revealing exceptional drug loading for the drug lansoprazole (LPZ) by 2D Cu-MONs as well as drug release in the acidic and neutral medium demonstrating that the 2D Cu-MON is an excellent carrier for antiulcer drug delivery. For environmental protection, the application of 2D Cu-MON was also examined toward the removal of various cationic and anionic dyes with excellent selectivity toward cationic dye removal. The plausible mechanism for dye removal indicated the involvement of cation-π and π-π interactions, for the effective adsorption of cationic dyes as well as a increase in the surface area of 2D Cu-MON by UILPE. Remarkably, the high drug loading and dye removal are imputed to the increase in surface area by UILPE. In a nutshell, the developed 2D Cu-MON will prove to be beneficial for application in the field of drug delivery as well as for wastewater treatment.
如今，二维金属有机纳米片（2D MONs）的制备已进入研究领域，吸引了全球研究人员的关注。然而，缺乏高效便捷的方法仍然是这些二维金属有机纳米片制造的瓶颈。在此，通过使用4,4'-三亚甲基二吡啶（TMDP）作为有机连接体，采用简便的搅拌方法合成了一种二维金属有机框架（MOF），即二维铜基金属有机框架（2D Cu-MOF）。对所制备的金属有机框架进行了详细表征，基于单晶X射线衍射分析，确定二维铜基金属有机框架中的缠结层相互连接形成粗链。这些缠结层可通过超声诱导液相剥离（UILPE）轻松分离，得到二维铜基金属有机纳米片，通过廷德尔光散射以及诸如扫描电子显微镜（SEM）和透射电子显微镜（TEM）等详尽的显微镜探索得以证实。在药物递送领域评估了这种二维铜基金属有机纳米片的应用，结果表明二维铜基金属有机纳米片对兰索拉唑（LPZ）具有出色的载药量，并且在酸性和中性介质中都能实现药物释放，这表明二维铜基金属有机纳米片是抗溃疡药物递送的优良载体。为了环境保护，还研究了二维铜基金属有机纳米片对各种阳离子和阴离子染料的去除应用，其对阳离子染料去除具有出色的选择性。染料去除的可能机制表明，阳离子-π和π-π相互作用参与其中，实现了阳离子染料的有效吸附以及通过UILPE增加了二维铜基金属有机纳米片的表面积。值得注意的是，高载药量和染料去除归因于通过UILPE增加的表面积。简而言之，所开发的二维铜基金属有机纳米片将被证明在药物递送领域以及废水处理中具有应用价值。
