Gupta Mayank, Sahana Sunanda, Sharma Vivekanand, Bharadwaj Parimal K
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
Dalton Trans. 2019 Jun 14;48(22):7801-7808. doi: 10.1039/c9dt00548j. Epub 2019 May 9.
A novel benzothiazole-based cryptand was designed and synthesized, and it exhibited high fluorescence intensity in the presence of Zn ions based on the metal chelation inhibition of the excited state intramolecular proton transfer (ESIPT) process. The structure of the cryptand was confirmed by NMR, mass spectroscopy and X-ray crystallography. Importantly, this probe showed high selectivity over other biologically relevant metal ions and anions and a detection limit of 0.20 μM, which is acceptable within the EPA (US) limit.
设计并合成了一种新型的基于苯并噻唑的穴状配体，基于其对激发态分子内质子转移（ESIPT）过程的金属螯合抑制作用，该穴状配体在锌离子存在下表现出高荧光强度。通过核磁共振、质谱和X射线晶体学确定了穴状配体的结构。重要的是，该探针对其他生物相关金属离子和阴离子具有高选择性，检测限为0.20 μM，在美国环境保护局（EPA）规定的限值范围内，这是可以接受的。
