Abtahi-Naeini Bahareh, Momen Tooba, Amiri Rezvan, Rajabi Parvin, Rastegarnasab Fereshte
Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Case Rep Dermatol Med. 2023 Mar 31;2023:6353919. doi: 10.1155/2023/6353919. eCollection 2023.
Metformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity of metformin, clinicians need to be aware of uncommon drug reactions for proper diagnosis and treatment. Herein, we report a 43-year-old man with generalized bullous lesions with a positive dechallenge-rechallenge test diagnosed as metformin-induced generalized bullous fixed-drug eruption. Metformin dosage was stopped and lesions were treated with topical clobetasol propionate and oral prednisolone and cyclosporine-A. After a 6-month follow-up, he was well without any relapsing episodes.
二甲双胍是糖尿病患者常用的药物。它会引发不同的并发症，包括皮肤不良反应。二甲双胍诱发的固定性药疹（FDE）仅有少数病例报道。由于二甲双胍的广泛使用，临床医生需要了解这些不常见的药物反应以便进行正确的诊断和治疗。在此，我们报告一名43岁男性，出现全身性水疱性皮损，激发-再激发试验呈阳性，被诊断为二甲双胍诱发的全身性水疱性固定性药疹。停用二甲双胍剂量，并使用丙酸氯倍他索外用以及泼尼松龙和环孢素A口服进行治疗。经过6个月的随访，他情况良好，无任何复发情况。
