人类T2R38苦味受体表达与COVID-19：从免疫到预后

Human T2R38 Bitter Taste Receptor Expression and COVID-19: From Immunity to Prognosis.

作者信息

Bethineedi Lakshmi Deepak, Baghsheikhi Hediyeh, Soltani Afsaneh, Mafi Zahedeh, Samieefar Noosha, Sanjid Seraj Shaikh, Khazeei Tabari Mohammad Amin

机构信息

Andhra Medical College, Visakhapatnam, Andhra Pradesh, India.

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Avicenna J Med Biotechnol. 2023 Apr-Jun;15(2):118-123.

PMID:37034895

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10073923/

Abstract

BACKGROUND

Bitter taste-sensing type 2 receptor (T2Rs or TAS2Rs) found on ciliated epithelial cells and solitary chemosensory cells have a role in respiratory tract immunity. T2Rs have shown protection against SARS-CoV-2 by enhancing the innate immune response. The purpose of this review is to outline the current sphere of knowledge regarding this association.

METHODS

A narrative review of the literature was done by searching (T2R38 OR bitter taste receptor) AND (COVID-19 OR SARS-CoV-2) keywords in PubMed and google scholar.

RESULTS

T2R38, an isoform of T2Rs encoded by the gene, may have a potential association between phenotypic expression of T2R38 and prognosis of COVID-19. Current studies suggest that due to different genotypes and widespread distributions of T2Rs within the respiratory tract and their role in innate immunity, treatment protocols for COVID-19 and other respiratory diseases may change accordingly. Based on the phenotypic expression of T2R38, it varies in innate immunity and host response to respiratory infection, systemic symptoms and hospitalization.

CONCLUSION

This review reveals that patients' innate immune response to SARS-COV-2 could be influenced by T2R38 receptor allelic variations.

摘要

背景

在纤毛上皮细胞和孤立化学感受细胞上发现的苦味味觉感受2型受体（T2Rs或TAS2Rs）在呼吸道免疫中发挥作用。T2Rs已显示出通过增强先天免疫反应来抵御严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。本综述的目的是概述关于这种关联的当前知识范围。

方法

通过在PubMed和谷歌学术中搜索（T2R38或苦味受体）以及（2019冠状病毒病或SARS-CoV-2）关键词对文献进行叙述性综述。

结果

T2R38是由该基因编码的T2Rs的一种亚型，其表型表达与2019冠状病毒病的预后之间可能存在潜在关联。目前的研究表明，由于T2Rs在呼吸道内的不同基因型和广泛分布及其在先天免疫中的作用，2019冠状病毒病和其他呼吸道疾病的治疗方案可能会相应改变。基于T2R38的表型表达，其在先天免疫以及宿主对呼吸道感染、全身症状和住院治疗的反应方面存在差异。