Ohye C, Narabayashi H
J Neurosurg. 1979 Mar;50(3):290-7. doi: 10.3171/jns.1979.50.3.0290.
Unitary or a group of unitary responses recorded extracellularly in the rostral part of the thalamic sensory nucleus during the course of thalamotomy for parkinsonian and other kinds of tremor were studied. They were the first sensory neurons encountered in the frontocaudal approach of the stereotaxic needle to the therapeutic target at the lower border of the ventralis intermedius nucleus. The spike discharges, isolated from high neural noise background, responded to passive and/or active movement of joint or muscle on the contralateral extremity but never to light tactile stimuli. In five cases, electrical stimulation of the corresponding peripheral nerves elicited the same spike discharge at short and fixed latency of about 12 msec. Weak electrical stimulation given to each thalamic point produced paresthetic or electric sensation around the receptive field, and stronger stimulation induced tremor-like movement in the area involving the receptive field. Finally, a small coagulation lesion in this thalamic point resulted in immediate relief of tremor without any sensory deficit. From these findings, the possibility is considered that in the human, this particular thalamic zone could be the ventralis intermedius nucleus, which is separable from the surrounding nuclei and is related to tremor mechanism.
在对帕金森病及其他类型震颤进行丘脑切开术的过程中，研究了在丘脑感觉核嘴侧部分细胞外记录到的单一或一组单一反应。它们是立体定向针从前向后进入腹中间核下缘治疗靶点过程中遇到的首批感觉神经元。从高神经噪声背景中分离出的锋电位放电，对患侧肢体关节或肌肉的被动和/或主动运动有反应，但对轻触觉刺激无反应。在5例中，电刺激相应的外周神经在约12毫秒的短而固定的潜伏期诱发相同的锋电位放电。对每个丘脑点给予弱电刺激会在感受野周围产生感觉异常或电击感，而较强刺激会在涉及感受野的区域诱发震颤样运动。最后，在该丘脑点进行小的凝固性损伤可立即缓解震颤且无任何感觉缺失。基于这些发现，推测在人类中，这个特定的丘脑区域可能是腹中间核，它与周围核团可分离且与震颤机制有关。
