Yin Zhaoyang, Gong Ge, Wang Xiang, Liu Wei, Wang Bin, Yin Jian
Department of Orthopedics, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China.
Department of Geriatrics, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Front Cell Dev Biol. 2023 Mar 24;11:1123753. doi: 10.3389/fcell.2023.1123753. eCollection 2023.
Periprosthetic osteolysis (PPO) induced by wear particles is an important cause of aseptic loosening after artificial joint replacement, among which the imbalance of osteogenesis and osteoclastic processes occupies a central position. The cells involved in PPO mainly include osteoclasts (macrophages), osteoblasts, osteocytes, and fibroblasts. RANKL/RANK/OGP axis is a typical way for osteolysis. Autophagy, a mode of regulatory cell death and maintenance of cellular homeostasis, has a dual role in PPO. Although autophagy is activated in various periprosthetic cells and regulates the release of inflammatory cytokines, osteoclast activation, and osteoblast differentiation, its beneficial or detrimental role remains controversy. In particular, differences in the temporal control and intensity of autophagy may have different effects. This article focuses on the role of autophagy in PPO, and expects the regulation of autophagy to become a powerful target for clinical treatment of PPO.
磨损颗粒诱导的假体周围骨溶解（PPO）是人工关节置换术后无菌性松动的重要原因，其中成骨与破骨过程的失衡占据核心地位。参与PPO的细胞主要包括破骨细胞（巨噬细胞）、成骨细胞、骨细胞和成纤维细胞。RANKL/RANK/OGP轴是骨溶解的典型途径。自噬作为一种调节细胞死亡和维持细胞内稳态的方式，在PPO中具有双重作用。尽管自噬在各种假体周围细胞中被激活，并调节炎性细胞因子的释放、破骨细胞活化和成骨细胞分化，但其有益或有害作用仍存在争议。特别是，自噬在时间控制和强度上的差异可能产生不同的影响。本文重点探讨自噬在PPO中的作用，并期望对自噬的调控成为临床治疗PPO的有力靶点。
