Luxenberg M N, Guthrie T H
Ophthalmology. 1986 Apr;93(4):504-10. doi: 10.1016/s0161-6420(86)33708-4.
Eight patients, aged 62 to 85 years, with nine instances of histologically proven basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) involving the eyelids and periorbital tissues, were treated with systemic and/or local (iontophoresis) chemotherapy using cisplatin (Platinol) and doxorubicin (Adriamycin). All patients had either refused surgery, would have required extensive procedures, or had medical problems contraindicating surgery. Systemic chemotherapy induced a complete or partial remission in eight of nine lesions. No patient has required maintenance chemotherapy and no significant toxic side effects were encountered. The length of follow-up ranged from 2 to 50 months. Iontophoretic therapy with cisplatin was used to treat five small foci of new, recurrent or persistent tumor(s) in three of these patients and resulted in a partial response in all five lesions. Systemic or local chemotherapy offers an alternative to current standard forms of treatment for BCC and SCC in selected cases.
8例年龄在62至85岁之间、患有9例经组织学证实累及眼睑和眶周组织的基底细胞癌（BCC）或鳞状细胞癌（SCC）的患者，接受了使用顺铂（铂尔定）和多柔比星（阿霉素）的全身和/或局部（离子导入）化疗。所有患者要么拒绝手术，要么需要进行广泛手术，要么存在手术禁忌的医学问题。全身化疗使9个病灶中的8个实现了完全或部分缓解。没有患者需要维持化疗，也未出现明显的毒副作用。随访时间为2至50个月。其中3例患者使用顺铂离子导入疗法治疗了5个新的、复发的或持续存在的小肿瘤病灶，所有5个病灶均有部分反应。在某些病例中，全身或局部化疗为目前BCC和SCC的标准治疗形式提供了一种替代方案。
