Alegre Adrián, Pino Ander, Jiménez Natalia, Jaén Pedro, Anitua Eduardo
Grupo de Dermatología Pedro Jaén, Madrid, Spain.
BTI Biotechnology Institute, Vitoria, Spain.
J Cutan Aesthet Surg. 2022 Oct-Dec;15(4):405-411. doi: 10.4103/JCAS.JCAS_160_21.
Acne vulgaris is a common condition that often results in secondary cutaneous damage in the form of scarring. Scars require shape-specific scaffolds. Recently, a new 3D gel derived from plasma rich in growth factors technology (PRGF) has been developed with the aim of overcoming these limitations.
The aim of this study was to preliminarily assess the clinical performance of the combination therapy with PRGF-gel (PG) and fractional ablative laser for post-acne scar amelioration.
Nine patients suffering from post-acne scars received a combination of PG and fractional ablative laser therapy. Macrophotographs were taken and patients completed a satisfaction survey. Images were also analyzed following the ECCA score. Clinicians were also asked to fulfill a clinical improvement score and any undesired side effects were recorded.
Patients were referred to be highly satisfied as an 8.7 ± 0.9 satisfaction score was achieved. Healthcare specialists objectivated that the scar reduction and overall skin quality at the end of the study had noticeably improved. The ECCA score showed a significant 55% of improvement compared with baseline. No major side effects were recorded, and the tolerance of the treatment was excellent.
The combined therapy with PG and fractional ablative laser might help in the management of post-acne scars and overall skin rejuvenation.
寻常痤疮是一种常见病症，常导致瘢痕形式的继发性皮肤损伤。瘢痕需要特定形状的支架。最近，一种源自富含生长因子血浆技术（PRGF）的新型3D凝胶已被开发出来，旨在克服这些局限性。
本研究的目的是初步评估PRGF凝胶（PG）联合剥脱性点阵激光治疗痤疮后瘢痕的临床效果。
9例痤疮后瘢痕患者接受了PG联合剥脱性点阵激光治疗。拍摄了宏观照片，患者完成了满意度调查。还根据ECCA评分对图像进行了分析。临床医生也被要求完成临床改善评分，并记录任何不良副作用。
患者满意度较高，满意度评分为8.7±0.9。医疗保健专家观察到，研究结束时瘢痕减轻，整体皮肤质量有显著改善。ECCA评分显示与基线相比有55%的显著改善。未记录到重大副作用，治疗耐受性良好。
PG联合剥脱性点阵激光治疗可能有助于痤疮后瘢痕的管理和整体皮肤年轻化。
