Chan Nicola P Y, Ho Stephanie G Y, Yeung Chi K, Shek Samantha Y N, Chan Henry H
Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong SAR, China.
Lasers Surg Med. 2010 Nov;42(9):615-23. doi: 10.1002/lsm.20974.
Ablative fractional resurfacing (AFR) is a new modality for photorejuvenation and acne scars which combines carbon dioxide (CO₂) laser ablation with fractional photothermolysis. The objective is to evaluate the efficacy and side effects of a new fractional CO₂ ablative device (Fraxel Re:pair) for skin rejuvenation and acne scars in Asians.
Nine patients underwent one full-face treatment. The energy levels ranged from 30-70 mJ with coverage between 30% and 45%. Improvement in skin texture, laxity, wrinkles, enlarged pores, overall pigmentation irregularity, and adverse effects were assessed up to 6 months post-treatment. Standardized photographs using the Canfield Visia CR system® were assessed by two independent observers. Subjective improvement was assessed by patient questionnaires.
Nine Chinese patients (skin types III and IV, mean age 44.8) were included. Statistically significant improvements were seen for skin texture, skin laxity, wrinkles, enlarged pores, and acne scars. The post-inflammatory hyperpigmentation rate was 55.5% and 11.1% at 1 and 6 months post-treatment, respectively. Eighty-six percent of patients were overall satisfied to very satisfied with the treatment.
Ablative fractional CO₂ laser resurfacing was overall safe and effective for skin rejuvenation and acne scars in Asians. However, in view of the high post-inflammatory rate and the statistically significant but only mild to moderate improvement after a single treatment as observed in this study, there is a need to review the current role of fractional ablative CO₂ laser treatment as compared to fractional non-ablative for skin rejuvenation and acne scar treatment in Asians.
剥脱性点阵激光换肤术（AFR）是一种用于皮肤年轻化和痤疮瘢痕治疗的新方法，它将二氧化碳（CO₂）激光消融与点阵光热分解技术相结合。目的是评估一种新型的点阵式CO₂剥脱设备（飞梭镭射修复版）对亚洲人皮肤年轻化和痤疮瘢痕的疗效及副作用。
9例患者接受了一次全脸治疗。能量水平范围为30 - 70 mJ，覆盖率在30%至45%之间。在治疗后长达6个月的时间里，评估皮肤质地、松弛度、皱纹、毛孔粗大、整体色素沉着不均的改善情况以及不良反应。使用Canfield Visia CR系统®拍摄的标准化照片由两名独立观察者进行评估。通过患者问卷评估主观改善情况。
纳入9例中国患者（皮肤类型为III型和IV型，平均年龄44.8岁）。在皮肤质地、皮肤松弛度、皱纹、毛孔粗大及痤疮瘢痕方面均观察到具有统计学意义的改善。治疗后1个月和6个月的炎症后色素沉着率分别为55.5%和11.1%。86%的患者对治疗总体满意至非常满意。
剥脱性点阵CO₂激光换肤术对亚洲人皮肤年轻化和痤疮瘢痕治疗总体上是安全有效的。然而，鉴于本研究中观察到的高炎症后色素沉着率以及单次治疗后虽具有统计学意义但仅为轻度至中度的改善情况，与非剥脱性点阵激光相比，有必要重新审视剥脱性点阵CO₂激光治疗在亚洲人皮肤年轻化和痤疮瘢痕治疗中的当前作用。
