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Editorial: Cellular senescence in physiology and pathophysiology.社论：生理与病理生理学中的细胞衰老
Front Physiol. 2023 Mar 22;14:1173284. doi: 10.3389/fphys.2023.1173284. eCollection 2023.
2
The implication of ROCK 2 as a potential senotherapeutic target via the suppression of the harmful effects of the SASP: Do senescent cancer cells really engulf the other cells?通过抑制衰老相关分泌表型（SASP）的有害作用，ROCK 2作为潜在的衰老治疗靶点的意义：衰老癌细胞真的会吞噬其他细胞吗？
Cell Signal. 2021 Aug;84:110007. doi: 10.1016/j.cellsig.2021.110007. Epub 2021 Apr 13.
3
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Senotherapeutic-like effect of Silybum marianum flower extract revealed on human skin cells.水飞蓟宾花提取物对人皮肤细胞表现出类 senotherapeutic 效应。
PLoS One. 2021 Dec 16;16(12):e0260545. doi: 10.1371/journal.pone.0260545. eCollection 2021.
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Mitochondria-targeted senotherapeutic interventions.线粒体靶向衰老治疗干预。
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The Jekyll and Hyde of Cellular Senescence in Cancer.细胞衰老在癌症中的亦正亦邪。
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The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications.蛋白质组学监测衰老相关分泌表型及其他方面的威力：迈向临床应用。
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本文引用的文献

1
Senescent cells and SASP in cancer microenvironment: New approaches in cancer therapy.癌症微环境中的衰老细胞与衰老相关分泌表型：癌症治疗的新方法。
Adv Protein Chem Struct Biol. 2023;133:115-158. doi: 10.1016/bs.apcsb.2022.10.002. Epub 2022 Nov 25.
2
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.PLK1通过延缓髓核细胞衰老减轻椎间盘退变。
Front Cell Dev Biol. 2022 Mar 14;10:819262. doi: 10.3389/fcell.2022.819262. eCollection 2022.
3
The Cancer SENESCopedia: A delineation of cancer cell senescence.《癌症衰老词典》：癌症细胞衰老描绘。
Cell Rep. 2021 Jul 27;36(4):109441. doi: 10.1016/j.celrep.2021.109441.
4
The implication of ROCK 2 as a potential senotherapeutic target via the suppression of the harmful effects of the SASP: Do senescent cancer cells really engulf the other cells?通过抑制衰老相关分泌表型（SASP）的有害作用，ROCK 2作为潜在的衰老治疗靶点的意义：衰老癌细胞真的会吞噬其他细胞吗？
Cell Signal. 2021 Aug;84:110007. doi: 10.1016/j.cellsig.2021.110007. Epub 2021 Apr 13.
5
A Blueprint for Characterizing Senescence.衰老特征描述蓝图
Cell. 2020 Nov 25;183(5):1143-1146. doi: 10.1016/j.cell.2020.10.032. Epub 2020 Oct 30.
6
A proteomic atlas of senescence-associated secretomes for aging biomarker development.衰老相关分泌表型的蛋白质组学图谱用于衰老生物标志物的开发。
PLoS Biol. 2020 Jan 16;18(1):e3000599. doi: 10.1371/journal.pbio.3000599. eCollection 2020 Jan.
7
Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival.化疗诱导的衰老癌细胞吞噬其他细胞以增强其存活。
J Cell Biol. 2019 Nov 4;218(11):3827-3844. doi: 10.1083/jcb.201904051. Epub 2019 Sep 17.
8
The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway.强心苷诱导的衰老细胞形态与Rho/Rho激酶信号通路之间的联系。
Cytoskeleton (Hoboken). 2018 Nov;75(11):461-471. doi: 10.1002/cm.21502. Epub 2018 Dec 7.
9
Unmasking Transcriptional Heterogeneity in Senescent Cells.揭示衰老细胞中的转录异质性。
Curr Biol. 2017 Sep 11;27(17):2652-2660.e4. doi: 10.1016/j.cub.2017.07.033. Epub 2017 Aug 30.
10
The senescence-associated secretory phenotype: the dark side of tumor suppression.衰老相关的分泌表型：肿瘤抑制的阴暗面。
Annu Rev Pathol. 2010;5:99-118. doi: 10.1146/annurev-pathol-121808-102144.

Editorial: Cellular senescence in physiology and pathophysiology.

作者信息

Ark Mustafa, Uddin Mohammad Nasir

机构信息

Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.

Department of Medical Physiology, Texas A&M Health Science Center School of Medicine/Baylor Scott & White Hospital, Temple, TX, United States.

出版信息

Front Physiol. 2023 Mar 22;14:1173284. doi: 10.3389/fphys.2023.1173284. eCollection 2023.

DOI:10.3389/fphys.2023.1173284
PMID:37035657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10073689/
Abstract
摘要