Office of Strategic Coordination, National Institutes of Health, Bethesda, MD 20892, USA; Division of Program Coordination, Planning, and Strategic Initiative, National Institutes of Health, Bethesda, MD 20892, USA.
National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Cell. 2020 Nov 25;183(5):1143-1146. doi: 10.1016/j.cell.2020.10.032. Epub 2020 Oct 30.
Given the heterogeneity of senescent cells, our knowledge of both the drivers and consequences of cellular senescence in tissues and organs remains limited, as is our understanding of how this process could be harnessed for human health. Here we identified five broad areas that would help propel the field forward.
鉴于衰老细胞的异质性,我们对组织和器官中细胞衰老的驱动因素和后果的了解仍然有限,我们对如何利用这一过程促进人类健康的理解也有限。在这里,我们确定了有助于推动该领域前进的五个广泛领域。