Siregar Fitri Dona, Hidayat Wahyu
Speciality Program of Oral Medicine, Faculty of Dentistry Universitas Padjadjaran, Bandung, West Java, Indonesia.
Department of Oral Medicine, Faculty of Dentistry Universitas Padjadjaran, Bandung, West Java, Indonesia.
Int Med Case Rep J. 2023 Apr 1;16:227-232. doi: 10.2147/IMCRJ.S402005. eCollection 2023.
Vitamin D is an essential steroid hormone that consists of two forms, namely vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), which can be obtained from exposure to sunlight, synthesis of vitamin D in the skin, food and dietary supplements. Prevalence of vitamin D deficiency in several countries including Indonesia is still high, while the role of vitamin D is very important including accelerating the wound healing process, increasing the immune system, anti-inflammatory, and anti-bacterial.
This case report aims to find out the role of vitamin D in the wound-healing process in the oral mucosa.
Two men went to the Oral Disease Clinic with complaints of canker sores on the oral mucosa for more than a month accompanied by pain. Intra-oral condition in the first patient showed multiple ulcers with yellowish white base surrounded by erythematous areas, well-defined, irregular with a size of 1.5 × 1 cm and 1 × 0.5 cm on the right and left buccal mucosa, while intra-oral in the second patient, a single ulcer with a base was found yellowish colour surrounded by erythematous area, oval measuring 3x1 cm, clearly demarcated with induration.
Laboratory examination of vitamin D in both patients showed decreased levels of vitamin D with values of 28.7 and 9.8 ng/mL.
Vitamin D supplementation has shown effectiveness in wound-healing processes in the oral mucosa.
维生素D是一种必需的类固醇激素，有两种形式，即维生素D2（麦角钙化醇）和维生素D3（胆钙化醇），可通过阳光照射、皮肤中维生素D的合成、食物和膳食补充剂获得。包括印度尼西亚在内的几个国家维生素D缺乏的患病率仍然很高，而维生素D的作用非常重要，包括加速伤口愈合过程、增强免疫系统、抗炎和抗菌。
本病例报告旨在探讨维生素D在口腔黏膜伤口愈合过程中的作用。
两名男性前往口腔疾病诊所，主诉口腔黏膜出现口腔溃疡一个多月并伴有疼痛。第一名患者的口腔内情况显示有多个溃疡，溃疡底部呈黄白色，周围有红斑区域，边界清晰，形状不规则，右侧和左侧颊黏膜的大小分别为1.5×1厘米和1×0.5厘米，而第二名患者的口腔内发现一个单一溃疡，底部呈黄色，周围有红斑区域，椭圆形，大小为3×1厘米，边界清晰且有硬结。
两名患者的维生素D实验室检查均显示维生素D水平降低，值分别为28.7和9.8纳克/毫升。
补充维生素D已显示出在口腔黏膜伤口愈合过程中的有效性。
