Periodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Egas Moniz-Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, Portugal.
Health Psychology Multidisciplinary Research Center, CRU, CiiEM, Egas Moniz-Cooperativa de Ensino Superior, 2829-511 Caparica, Almada, Portugal.
Nutrients. 2020 May 19;12(5):1471. doi: 10.3390/nu12051471.
Vitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, and impaired VD synthesis may expedite some of these conditions. In children, severe VDD can induce defective tooth mineralization, resulting in dentin and enamel defects. As a consequence, these defects may increase the risk of the onset and progression of dental caries. Further, VDD has been associated with higher prevalence of periodontitis and gingival inflammation, and several recent preclinical and clinical studies have unveiled potential pathways through which Vitamin D may interact with the periodontium. VDD correction through supplementation may contribute to a successful treatment of periodontitis; however, alveolar bone regeneration procedures performed in baseline VDD patients seem more prone to failure. Vitamin D may also be linked with some oral pathology entities such as certain oral cancers and events of osteonecrosis of the jaw. This review aims to provide comprehensive evidence of how VD levels should be considered to promote good oral health, and to summarize how VDD may hamper oral development and its role in certain oral conditions.
维生素 D（VD）水平在口腔健康领域越来越受到关注。在生长和成年期，VD 缺乏（VDD）与多种口腔健康障碍有关，而 VD 合成受损可能会加速其中一些疾病的发生。在儿童中，严重的 VDD 会导致牙齿矿化不良，导致牙本质和牙釉质缺陷。因此，这些缺陷可能会增加龋齿发生和进展的风险。此外，VDD 与牙周炎和牙龈炎症的高发率有关，最近的一些临床前和临床研究揭示了维生素 D 可能与牙周组织相互作用的潜在途径。通过补充来纠正 VDD 可能有助于成功治疗牙周炎；然而，在基线 VDD 患者中进行的牙槽骨再生程序似乎更容易失败。维生素 D 还可能与某些口腔病理学实体有关，例如某些口腔癌和颌骨坏死事件。本综述旨在提供全面的证据，说明应如何考虑 VD 水平以促进良好的口腔健康，并总结 VDD 如何阻碍口腔发育及其在某些口腔疾病中的作用。
