牙周病与偏头痛的相关性：一项大规模基于社区的横断面研究。

Association of periodontal disease with migraine: A large-scale community-based cross-sectional study.

机构信息

Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

Headache. 2023 Apr;63(4):539-548. doi: 10.1111/head.14491. Epub 2023 Apr 10.

DOI:10.1111/head.14491

PMID:37036129

Abstract

BACKGROUND

Periodontal disease may drive a systemic inflammatory response that triggers migraine; however, the association between periodontal disease and migraine has rarely been investigated in a community-based setting.

METHODS

This cross-sectional study included 66,109 participants aged 30 to 70 years from Taiwan Biobank (TWB). A structured questionnaire was administered to participants, who were also subjected to whole-genome single nucleotide polymorphism genotyping using the customized Axiom-TWB array. To identify subjects with periodontal disease and migraine, the computerized linkage of data obtained from TWB and the National Health Insurance Research Database was performed. Participants were evaluated for their genetic predisposition to migraine using a polygenic risk score. We examined and estimated the magnitude of associations between periodontal disease and migraine.

RESULTS

In this study, 4618 (4618/66,109; 7%) participants with migraine and 61,491 (61,491/66,109; 83%) participants without migraine were included. Participants with migraine exhibited a higher prevalence of periodontal disease than participants without migraine (4324/4618; 94% vs. 56,036/61,491; 91%). A significant positive association was observed between periodontal disease and migraine, with an adjusted odds ratio (OR ) of 1.40 (95% confidence interval [CI] = 1.24-1.59; p < 0.001). The association remained consistent even after excluding participants with other comorbidities (OR = 1.34; 95% CI = 1.16-1.55; p < 0.001). Moreover, the positive association between periodontal disease and migraine remained significant across the subgroups of age, sex, other comorbidities, and classified polygenic risk scores of migraine, with the OR ranging from 1.26 to 1.78.

CONCLUSIONS

A significant positive association was observed between periodontal disease and migraine. Future studies need to explore the biological mechanisms of how periodontal disease might affect migraine.

摘要

背景

牙周病可能会引发全身性炎症反应，从而引发偏头痛；然而，牙周病与偏头痛之间的关联在基于社区的研究中很少被调查。

方法

本横断面研究纳入了来自台湾生物样本库（TWB）的 66109 名 30 至 70 岁的参与者。对参与者进行了结构化问卷调查，并使用定制的 Axiom-TWB 阵列对他们进行了全基因组单核苷酸多态性基因分型。为了确定患有牙周病和偏头痛的受试者，对 TWB 和全民健康保险研究数据库的数据进行了计算机链接。使用多基因风险评分评估偏头痛的遗传易感性。我们检查并估计了牙周病和偏头痛之间关联的程度。

结果

在这项研究中，4618 名（4618/66109；7%）参与者患有偏头痛，61491 名（61491/66109；83%）参与者没有偏头痛。患有偏头痛的参与者的牙周病患病率高于没有偏头痛的参与者（4324/4618；94% vs. 56036/61491；91%）。牙周病与偏头痛之间存在显著的正相关，调整后的优势比（OR）为 1.40（95%置信区间[CI] 1.24-1.59；p<0.001）。即使排除了其他合并症的参与者，这种关联仍然一致（OR=1.34；95%CI 1.16-1.55；p<0.001）。此外，在年龄、性别、其他合并症和偏头痛分类多基因风险评分的亚组中，牙周病与偏头痛之间的正相关仍然显著，OR 范围为 1.26 至 1.78。